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Completed

NCT Number: NCT00386854

Metabolic Study of Concentric and Eccentric Muscle Training

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

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Key information

Conditions

Lipid Metabolism Behavior Glucose Metabolism Disorders Hyperinsulinism Inflammation Insulin Resistance Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

30 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Vorarlberg Institute of Vascular Investigation and Treatment

Feldkirch, Vorarlberg, 6807, Austria

About this study

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy men and women
  • age over 30 years

Exclusion criteria

  • previous systematic endurance training (≥3 times per week ≥30 min)
  • body mass index >30 kg/m2
  • heavy smoking (>20 cigarettes per day)
  • regular alcohol consumption >60g per day
  • established musculoskeletal disease
  • history of cardiovascular disease
  • diabetes mellitus
  • unwillingness to stay in the area for the whole study period

Treatment and study plan

physical training

Behavioral

Primary outcomes

  1. Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.

Secondary outcomes

  1. Metabolic and anti-inflammatory effects induced by concentric muscle exercise.

Sponsors and collaborators

Lead sponsor

Vorarlberg Institute for Vascular Investigation and Treatment

Other

Registry information

Important dates

Study start
2003
Study completion
2003
First posted
Oct 12, 2006
Registry last updated
Oct 12, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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