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Completed

NCT Number: NCT00905892

Metabolic Fate Modifications of Saturated Fats After an Overfeeding

The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

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Key information

Conditions

Obesity Bacteremia Body Weight Endotoxemia Infections Inflammation Lipid Metabolism Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Signs and Symptoms Systemic Inflammatory Response Syndrome Toxemia

Age range

18 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre de recherche en nutrition humaine Rhone-Alpes

Pierre-Bénite, 69495, France

About this study

Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 to 55 years old
  • BMI 18 to 30 kg/m²
  • Stable physical activity
  • Safety subject during medical consultation

Exclusion criteria

  • Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
  • Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
  • Eating disorder
  • Intensive sportive activity
  • Subjects who Smoke
  • Claustrophobic subjects

Treatment and study plan

Hyperlipidic overfeeding

Dietary Supplement

100g per day of cheese + 40g per day of almonds + 20g per day of butter

Primary outcomes

  1. Post prandial partitioning of exogenous lipids

    Time frame: Before and after overfeeding

Secondary outcomes

  1. Genes expression in adipose and muscle tissues

    Time frame: Before and after overfeeding

Sponsors and collaborators

Lead sponsor

Centre de Recherche en Nutrition Humaine Rhone-Alpe

Other

Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

Registry information

Acronym: SURNUT

Important dates

Study start
2005
Primary completion
2009
Study completion
2010
First posted
May 21, 2009
Registry last updated
Jun 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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