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Completed

NCT Number: NCT01474226

Metabolic Availability of Lysine From Rice

The purpose of this study is to investigate the digestibility of the amino acid lysine in cooked rice in adult men using stable isotope technique.

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Key information

Conditions

Healthy Adults

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1

Primary location

The Hospital for Sick Children

Toronto, Ontario, M5G-1X8, Canada

About this study

The investigators objective is to determine the metabolic availability (MA) of lysine in cooked white rice protein using the indicator amino acid oxidation (IAAO) technique. Five men will receive graded levels (20, 40, and 60, and 70%) of the lysine requirement of 35 mg/kg/d as a crystalline AA mixture,and cooked rice protein (20, 40 and 60%), respectively.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Adult males (18 to 50years old)

Exclusion criteria

  • A history of recent weight loss or illness
  • Use of any medication at the time of entry into the study.

Treatment and study plan

Amino Acid Crystalline Lysine Amino Acid Mix

Dietary Supplement

crystalline lysine from AA MIX (20, 40, and 60% of the mean lysine requirement of 35 mg/kg/d) Lysine will be given in the form of L-Lysine-HCl, Sigma-Aldrich Brand.

Cooked Rice containing Lysine

Dietary Supplement

Lysine (20,40 and 60 % of the mean lysine requirement) from Cooked Rice

Primary outcomes

  1. Metabolic Availability of lysine

    Time frame: Baseline

    3 breath samples will be taken to provide a baseline F13CO2 measurement (Level of phenylalanine oxidation). Breath samples will be collected and analyzed for 13CO2 enrichment.

  2. Metabolic Availability of lysine

    Time frame: 15 min after intake of the fourth hourly meal (before tracer infusion))

    3 breath samples will be taken to provide a baseline F13CO2 measurement (Level of phenylalanine oxidation). Breath samples will be collected and analyzed for 13CO2 enrichment.

  3. Metabolic Availability of lysine

    Time frame: 30 min after intake of the fourth hourly meal (before tracer infusion))

    3 breath samples will be taken to provide a baseline F13CO2 measurement (Level of phenylalanine oxidation). Breath samples will be collected and analyzed for 13CO2 enrichment.

  4. Metabolic Availability of lysine

    Time frame: 45 min after intake of the fourth hourly meal (before tracer infusion))

    3 breath samples will be taken to provide a baseline F13CO2 measurement (Level of phenylalanine oxidation). Breath samples will be collected and analyzed for 13CO2 enrichment.

Secondary outcomes

  1. Metabolic Availability of Lysine

    Time frame: Post Tracer Infusion (between 150 and 240 min of tracer infusion)

    4 breath samples will be taken to provide F13CO2 measurement (Level of phenylalanine oxidation).Breath samples will be collected and analyzed for 13CO2 enrichment.

Sponsors and collaborators

Lead sponsor

The Hospital for Sick Children

Other

Registry information

Official study title

Application of the Indicator Amino Acid Oxidation Technique for the Determination of Metabolic Availability of Lysine From Cooked Rice Protein in Adult Men

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Nov 18, 2011
Registry last updated
Jul 29, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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