Metabolic Adaptations to Diabetes in African Americans

We do not know why diabetic patients cannot protect themselves against low blood sugar. Therefore, in this study, we will perform a comprehensive assessment of the body's response to low blood sugar by measuring changes in blood hormones, blood sugar production, and nerve signals.

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Key information

Conditions

Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Hypoglycemia Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Morning and afternoon hypoglycemic episodes of 70, 60, or 50 mg/dl produce increased blunting of subsequent counterregulation dependent upon the depth of preceding hypoglycemia. We wanted to test this hypothesis in healthy African American individuals to determine if there is a difference in their responses to varying depths of hypoglycemia.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy males and females aged 18-40 yrs with no family history of diabetes mellitus.
All prospective volunteers will have routine blood tests to screen for biochemical, hormonal and hematological abnormalities.
Female volunteers will also undergo an HCG urine pregnancy test.

Exclusion criteria

Prior or current history of poor health
Abnormal results following blood and physical examination
Pregnancy

Treatment and study plan

glucose clamp

Procedure

2 hour hyperinsulinemic euglycemic clamp (90 mg/dl)

Primary outcomes

catecholamines

Time frame: 2 hours

Sponsors and collaborators

Lead sponsor

Vanderbilt University

Other

Registry information

Official study title

Metabolic Adaptations to Diabetes

Important dates

Study start: 1998
Primary completion: 2000
Study completion: 2010
First posted: Oct 27, 2008
Registry last updated: Dec 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed