Skip to main content
OpenTrials
Completed

NCT Number: NCT05535478

Deprescribing of Diabetes Regimens in Long Term Care Residents With Alzheimer's

Objectives To 1) examine the ability of the STRIDE (Simplification of Treatment Regimens and Individualized Diabetes Education) educational program to increase deprescribing of high hypoglycemia risk glucose-lowering medications (HRMs) among long term care facility (LTCF) residents with ADRD, 2) assess key implementation constructs (secondary outcomes) of the STRIDE program, including acceptability, appropriateness, and feasibility, and 3) validate the primary HRM use outcome measure.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Diabetes Brain Diseases Central Nervous System Diseases Dementia Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Hypoglycemia Hypoglycemia; Drug Mental Disorders Metabolic Diseases Nervous System Diseases Neurocognitive Disorders Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Joslin Diabetes Center

Boston, Massachusetts, 02215, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical staff at the LTCF (MDs, PAs, NPs, clinical pharmacists) - (Targeted providers for STRIDE program)
  • Clinical staff that participated in the STRIDE program (Providers doing stakeholder exit interviews)

Exclusion criteria

  • Consistent with the pragmatic nature of the trial, there are no exclusion criteria.

Treatment and study plan

STRIDE

Behavioral

a. Targeted providers for STRIDE program: i. Clinical staff at the LTCF who participate in deprescribing at the facilities (physicians (MDs), physician's assistants (PAs), nurse practitioners (NPs), clinical pharmacists): clinical staff members caring for LTCF residents with ADRD and diabetes at 6 LTCFs in the Ohio and Michigan areas will be invited via email from the LTCF leadership to participate in the STRIDE education program. The STRIDE program consist of practical algorithms and educational material, which they are free to view at any time, and participation in 2 webinars and monthly telementoring calls

Primary outcomes

  1. Change in proportion of long term care facility (LTCF) residents with Alzheimer's disease adn related dementias (ADRD) and diabetes with high risk medications (HRM) use

    Time frame: Baseline vs 6 months

    HRM use will include any sulfonylurea use (i.e., glyburide, glipizide, glimepiride, or chlorpropamide) and any insulin use.

Secondary outcomes

  1. Acceptability of the STRIDE Educational Program

    Time frame: 6 months

    The extent to which the program is agreeable to LTCF staff- using the Acceptability of Intervention Measure (AIM)

  2. Appropriateness of the STRIDE Educational Program

    Time frame: 6 months

    The extent to which the program is suitable for a particular purpose, i.e., to improve the frequency at which LTCF staff attempt diabetes medication regimen deprescribing- using the Intervention Appropriateness Measure (IAM)

  3. Feasibility of the STRIDE Educational Program

    Time frame: 6 months

    The extent to which the program is practical at the LTCF level- using the Feasibility of Intervention Measure (FIM)

Sponsors and collaborators

Lead sponsor

Joslin Diabetes Center

Other

Collaborators

  • Brown University
  • Theoria Medical

Registry information

Official study title

Deprescribing of Diabetes Treatment Regimens in Long Term Care (LTC) Residents With Alzheimer's Disease or Related Dementias (ADRD)

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Sep 10, 2022
Registry last updated
Jul 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.