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NCT Number: NCT07491250

Mesh Infection After Hernioplasty: Complete vs Partial Removal - Retrospective Study on Outcomes and Pathogen Analysis

Background: Mesh infection after tension-free inguinal hernia repair (IHR) is rare and challenging. When conservative treatment fails, surgery is often required. This study compared clinical outcomes of complete versus partial mesh removal in affected patients.

Materials and Methods: We retrospectively analyzed patients who underwent surgery for mesh infection after IHR in our hospital between January 2016 and December 2025. Baseline data, perioperative indicators, postoperative complications, and microbiological results were compared between the complete and partial removal groups.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

We conducted a single-center, retrospective case series analysis. We included patients who developed mesh infection after tension-free IHR and underwent surgical treatment at our center between January 2016 and December 2025. Patients with mesh infection after incisional, parastomal, or umbilical hernia repair were excluded. We also excluded patients who improved with conservative treatment and did not undergo surgery.

We collected the following data: demographic characteristics, comorbidities, laboratory and imaging results, characteristics of the primary hernia surgery, infection characteristics, intraoperative data, and postoperative outcomes. All data were entered into a standardized database. Follow-up was conducted through outpatient visits and telephone interviews. The last follow-up was on October 30, 2025.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent tension-free inguinal hernioplasty with mesh placement.
  • Patients diagnosed with mesh infection requiring surgical re-intervention.
  • Patients who underwent complete or partial mesh removal surgery.
  • Availability of complete medical records and follow-up data.

Exclusion criteria

  • Patients with mesh infection managed conservatively (without surgical removal).
  • Patients with missing critical data (e.g., intraoperative findings, pathogen results, or follow-up).
  • Patients with concomitant procedures that could confound outcomes (e.g., simultaneous other hernia repair).
  • Patients lost to follow-up immediately after discharge (no postoperative assessment).

Treatment and study plan

Complete mesh removal

Procedure

Total explantation of the entire prosthetic mesh, including all visible portions and fixation sutures, regardless of the extent of infection.

Partial mesh removal

Procedure

Excision of only the infected or non-incorporated portion of the mesh, with preservation of the well-incorporated, uninfected segment left in situ.

Primary outcomes

  1. Hernia Recurrence Rate

    Time frame: From date of surgery to December 2025

    Presence of clinically or radiologically confirmed recurrent inguinal hernia at the site of previous hernioplasty following mesh removal surgery.

  2. Infection Recurrence Rate

    Time frame: From date of surgery to December 2025

    Recurrence of surgical site infection at the same location after initial surgical treatment for mesh infection, confirmed by clinical signs (e.g., erythema, purulent drainage, sinus tract formation) and/or positive microbiological culture.

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaoyu Peng, MD

CONTACT

[email protected]

+8619121706827

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

A Retrospective Study: Complete vs Partial Mesh Removal for Mesh Infection After Hernioplasty - Clinical Outcomes and Pathogen Analysis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 24, 2026
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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