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OpenTrials
Completed

NCT Number: NCT02887105

Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident

The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed.

The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.

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Key information

Conditions

Cerebrovascular Accident Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Neurologie - Hôpital Bon Secours - CHR de Metz-Thionville, Metz, France

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About this study

Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin
  • Right-handed
  • Possible cooperation: understanding of French instructions
  • Normal or corrected vision
  • Normal or corrected hearing
  • Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient
  • Possible follow up of patient

Exclusion criteria

  • Hearing problems
  • Vision problems
  • Right hemiplegia or acute monoparesis of right upper limb
  • Hemispatial neglect
  • Apraxia
  • Psychiatric or neurological history possibly interfering with neuropsychological evaluation
  • Important defect of working memory or executive functions

Treatment and study plan

Standard neuropsychological assessment

Other

Brain MRI

Other

Primary outcomes

  1. State of anxiety evaluated with STAI-YA scale

    Time frame: up to 1 month (from CVA)

  2. State of anxiety evaluated with STAI-YA scale

    Time frame: 6 months (from CVA)

  3. Anxiety proneness evaluated with STAI-YB scale

    Time frame: up to 1 month (from CVA)

  4. Anxiety proneness evaluated with STAI-YB scale

    Time frame: 6 months (from CVA)

  5. Apprehension anxiety evaluated with Penn State Worry Questionnaire

    Time frame: up to 1 month (from CVA)

  6. Apprehension anxiety evaluated with Penn State Worry Questionnaire

    Time frame: 6 months (from CVA)

  7. Evaluation of working memory updating with N-back verbal and visuospatial task

    Time frame: up to 1 month (from CVA)

  8. Evaluation of working memory updating with N-back verbal and visuospatial task

    Time frame: 6 months (from CVA)

  9. Evaluation of working memory inhibition with Stimulus-response compatibility task

    Time frame: up to 1 month (from CVA)

  10. Evaluation of working memory inhibition with Stimulus-response compatibility task

    Time frame: 6 months (from CVA)

  11. Evaluation of working memory flexibility with Switching task

    Time frame: up to 1 month (from CVA)

  12. Evaluation of working memory flexibility with Switching task

    Time frame: 6 months (from CVA)

  13. Evaluation of verbal working memory with Wechsler memory scale

    Time frame: up to 1 month (from CVA)

  14. Evaluation of verbal working memory with Wechsler memory scale

    Time frame: 6 months (from CVA)

  15. Evaluation of visuospatial working memory with Wechsler memory scale

    Time frame: up to 1 month (from CVA)

  16. Evaluation of visuospatial working memory with Wechsler memory scale

    Time frame: 6 months (from CVA)

  17. Evaluation of visual episodic memory with Rey and Taylor figure test

    Time frame: 6 months (from CVA)

  18. Evaluation of verbal episodic memory with RL/RI 16 item test

    Time frame: 6 months (from CVA)

Secondary outcomes

  1. Hemispheric lateralization of lesions detected with MRI

    Time frame: up to 1 month from CVA

  2. Depression state evaluated with Back depression inventory

    Time frame: up to 1 month (from CVA)

  3. Depression state evaluated with Back depression inventory

    Time frame: 6 months (from CVA)

  4. Quality of life evaluated with SF-36 test

    Time frame: after 6 months from CVA

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Acronym: MEMOIRE ET EMO

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Sep 1, 2016
Registry last updated
Sep 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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