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NCT Number: NCT07496398

Median and Ulnar Nerve Function in Tattoo Artists

This case-control study aims to investigate the effects of occupational hand-arm vibration exposure on median and ulnar nerve functions in tattoo artists. Chronic exposure to vibration generated by tattoo machines may lead to neurosensory impairment, reduced tactile sensitivity, and decreased hand strength. Objective assessments including nerve provocation tests, sensory threshold evaluation, two-point discrimination, vibration perception, grip and pinch strength measurements, and validated patient-reported outcome questionnaires will be used. Findings will be compared with age- and sex-matched healthy controls.

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Key information

About this study

This observational cross-sectional case-control study evaluates neurosensory and motor function differences between professional tattoo artists exposed to long-term occupational vibration and healthy controls. Chronic exposure to hand-arm vibration (HAV) has been associated with peripheral neuropathy, entrapment neuropathies, and sensory receptor dysfunction.

Participants will undergo standardized assessment including:

Tinel, Phalen, reverse Phalen, and elbow flexion tests

Semmes-Weinstein monofilament testing

Two-point discrimination

Vibration perception testing (30 Hz and 256 Hz)

Grip and pinch strength measurements

Brief Michigan Hand Outcomes Questionnaire

Boston Carpal Tunnel Questionnaire

The study aims to determine whether occupational vibration exposure is associated with measurable alterations in median and ulnar nerve sensory and motor function.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Professional tattoo artists with at least 1 year of occupational experience (case group)
  • Healthy individuals without occupational vibration exposure (control group)
  • Voluntary participation and provision of informed consent
  • No upper extremity trauma or surgery within the last 6 months

Exclusion criteria

  • Diagnosis of diabetes mellitus
  • Diagnosis of peripheral neuropathy
  • History of cervical radiculopathy or cervical disc herniation
  • History of upper extremity surgery or injury
  • Presence of rheumatologic or systemic inflammatory diseases
  • Pregnancy
  • Substance or alcohol abuse
  • Engagement in a second occupation involving repetitive hand use or vibration exposure

Treatment and study plan

Primary outcomes

  1. Semmes-Weinstein Monofilament Threshold

    Time frame: Baseline (single assessment session)

    Assessment of light touch sensory threshold using Semmes-Weinstein monofilaments applied to the index and little fingers.

Secondary outcomes

  1. Two-Point Discrimination

    Time frame: Baseline (single assessment session)

    Minimum distance (mm) at which two points are perceived as separate on index and little fingers

  2. Vibration Perception Duration

    Time frame: Baseline (single assessment session)

    Duration (seconds) of vibration perception using tuning fork (30 Hz and 256 Hz)

  3. Grip Strength

    Time frame: Baseline (single assessment session)

    Maximal hand grip strength measured using a dynamometer (kg)

  4. Pinch Strength

    Time frame: Baseline (single assessment session)

    Lateral and tip pinch strength measured using a pinch gauge (kg)

  5. Boston Carpal Tunnel Questionnaire Score

    Time frame: Baseline (single assessment session)

    Symptom severity and functional status scores (1-5 scale)

  6. Brief Michigan Hand Outcomes Questionnaire Score

    Time frame: Baseline (single assessment session)

    Hand function score normalized to a 0-100 scale

  7. Nerve Provocation Test Positivity

    Time frame: Baseline (single assessment session)

    Presence of positive findings in Tinel, Phalen, reverse Phalen, and elbow flexion tests

Study contacts

Contact information is provided by the study sponsor or research team.

Sedanur Güngör, MSc.

CONTACT

[email protected]

+905334480698

Sponsors and collaborators

Lead sponsor

Gazi University

Other

Registry information

Official study title

Occupational Hand-Arm Vibration Exposure and Its Effects on Median and Ulnar Nerve Function in Tattoo Artists: A Case-Control Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 27, 2026
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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