Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer

The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is:

• Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients?

Participants:

Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Neuro-Oncology MRI Imaging Tumor Immune Microenvironment

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

the Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

conventional MRI revealed intracranial space-occupying lesions and suspected high-grade gliomas, brain metastases and meningiomas；
It is planned to perform a brain tumor resection surgery in this institution.

Exclusion criteria

other CNS diseases in addition to brain tumors;
pathologically confirmed brain tumors not belonging to any of the three selected types;
contraindications to the use of gadolinium contrast, including hypersensitivity to contrast agents, renal dysfunction, pregnancy or lactation;
contraindications to MRI;
poor image quality unsuitable for subsequent analyses;
age younger than 18 years.

Treatment and study plan

Primary outcomes

Postoperative Progression-Free Survival

Time frame: 6months，12months，24months

Postoperative Progression-Free Survival is defined as the time interval from the date of surgical intervention until the first occurrence of either documented disease progression or death from any cause

Sponsors and collaborators

Lead sponsor

Second Xiangya Hospital of Central South University

Other

Registry information

Official study title

The Second Xiangya Hospital of Central South University

Important dates

Study start: 2023
Primary completion: 2028
Study completion: 2030
First posted: Sep 22, 2025
Registry last updated: Sep 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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