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Completed

NCT Number: NCT00929123

Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.

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Key information

Conditions

Carpal Tunnel Syndrome Cumulative Trauma Disorders Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

University of Florida

Gainesville, Florida, 32611, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 to 70 years of age
  • signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion criteria

  • non english speaking
  • prior surgery for carpal tunnel syndrome
  • systemic condition known to affect sensation
  • chronic pain condition other than carpal tunnel syndrome

Treatment and study plan

neural mobilization

Procedure

manual therapy technique known to directly stress the median nerve

Other names: upper limb tension test with median nerve bias

sham neural mobilization

Procedure

sham technique mimicking the neural mobilization which is not specific to the median nerve

Healthy controls

Other

People without carpal tunnel syndrome for comparison

Primary outcomes

  1. thermal and pressure pain sensitivity

    Time frame: immediate effect

Secondary outcomes

  1. grip strength

    Time frame: 3 weeks

  2. wrist range of motion

    Time frame: 3 weeks

  3. clinical pain

    Time frame: 3 weeks

  4. self report of disability

    Time frame: 3 weeks

  5. median nerve function

    Time frame: 3 weeks

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Collaborators

  • National Center for Complementary and Integrative Health (NCCIH)

Registry information

Important dates

Study start
2007
Primary completion
2008
Study completion
2009
First posted
Jun 26, 2009
Registry last updated
Mar 17, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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