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NCT Number: NCT07313085

Mechanisms of Fecal Incontinence in Wolfram Syndrome

In order to clarify the mechanism of fecal incontinence in in Wolfram syndrome and to characterize its risk factors, the examiner will reviewed the files of patients followed in a Reference Center for Rare Diseases in Ophthalmology.

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Key information

Conditions

Wolfram Syndrome Abnormalities, Multiple Blindness Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Cranial Nerve Diseases Deaf-Blind Disorders Deafness Diabetes Insipidus Diabetes Mellitus Diabetes Mellitus, Type 1 Digestive System Diseases Ear Diseases Endocrine System Diseases Eye Diseases Eye Diseases, Hereditary Fecal Incontinence Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Genetic Diseases, Inborn Glucose Metabolism Disorders Hearing Disorders Hearing Loss Heredodegenerative Disorders, Nervous System Intestinal Diseases Kidney Diseases Male Urogenital Diseases Metabolic Diseases Nervous System Diseases Neurodegenerative Diseases Neurologic Manifestations Nutritional and Metabolic Diseases Optic Atrophies, Hereditary Optic Atrophy Optic Nerve Diseases Otorhinolaryngologic Diseases Pituitary Diseases Rectal Diseases Sensation Disorders Urogenital Diseases Urologic Diseases Vision Disorders

Sex eligibility

All sexes

Study type

Observational

Primary location

HEGP

Paris, 75015, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Wolfram syndrome

Exclusion criteria

  • no information concerning fecal incontinence in data records

Treatment and study plan

Retrospective case-control analysis

Other

retrospective analysis of data

Primary outcomes

  1. Urinary disorders

    Time frame: The date at the baseline

    number of patients with urinary disorder in each group according to the group

Secondary outcomes

  1. sleep apnea

    Time frame: The date the data will be analyzed at the baseline

    number of patients with sleep apnea in each group according to the group

  2. frequence of swallowing disroder

    Time frame: The data will be analyzed at baseline

    number of patients with swallowing disorders in each group according to the group

  3. frequence of diabetes insipidus

    Time frame: The data will be analyzed at baseline

    number of patients with diabetes insipidus in each group according to the group

  4. mutation type

    Time frame: The data will be analyzed at baseline

    report of mutations of WFS1 in each group

Study contacts

Contact information is provided by the study sponsor or research team.

christophe Orssaud, MD

CONTACT

[email protected]

33 156093466

Sponsors and collaborators

Lead sponsor

Hôpital Necker-Enfants Malades

Other

Registry information

Official study title

Physiopathogenic Mechanisms of Fecal Incontinence in Wolfram Syndrome

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 31, 2025
Registry last updated
Dec 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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