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Completed

NCT Number: NCT00564005

Mechanism and Efficacy of Rehabilitation Approaches

Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity principles and sound motor control theories.

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Key information

Conditions

Cerebrovascular Accidents Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

40 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chang Gung Memorial Hospital

Kwei-shan, Toayuan County, 333, Taiwan

About this study

Comparisons of constraint-induced therapy (CIT) vs. bilateral arm training (BIT)vs. combined therapy were made. Stroke patients will receive one of these three approaches and be evaluated pre- and post-treatment. the treatment will last 3 weeks and 5 days per week. The evaluation will include clinical measures of motor function, ADL, and quality of life, kinematic performance, and activation patterns of cortex.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a first-ever clinical cerebrovascular accident patients
  • at least 6 months post-stroke onset
  • premorbid right-hand dominance
  • demonstration of Brunnstrom stage III of the affected upper extremity
  • no excessive spasticity in the joints of the affected upper extremity

Exclusion criteria

  • a score of less than 24 on the Mini Mental State Exam
  • poor physical conditions that would interfere with participation
  • excessive pain in any joint that might limit participation

Treatment and study plan

Constraint-induced therapy (CIT)

Other

restraint of the unaffected arm and practice of the affected arm

Bilateral arm training (BAT)

Other

bilateral symmetric, repetitive arm training

Combined therapy (CT)

Other

combined different treatment approaches

Control Intervention

Behavioral

Conventional treatment program

Primary outcomes

  1. Cortical reorganization and kinematic analysis

    Time frame: 2008-2010

Secondary outcomes

  1. clinical measures at the impairment, activity, participation levels

    Time frame: 2008-2010

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Collaborators

  • National Health Research Institutes, Taiwan
  • National Science and Technology Council, Taiwan

Registry information

Official study title

Mechanisms and Long-term Effects of Separate vs. Coupled Rehabilitation Approaches After Stroke

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Nov 27, 2007
Registry last updated
Feb 11, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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