Multimodal Retinal Imaging of Cerebrovascular Stroke

The hypothesis is that in patients with stroke, abnormalities of retinal microvascularization shown on color fundus photography and the depletion of retinal capillary density evaluated by OCT-A are markers of acute impairment of microcirculation of the central nervous system and are correlated with lesions on brain imaging.

Patients hospitalized for stroke MRI-confirmed, will be included. An ophthalmologic assessment including color fundus photography (CFP) and OCT-A will be carried out after stabilization and at 3 months follow-up. Outcomes assessor will be blinded.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebral Small Vessel Diseases Cerebrovascular Accidents Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation A de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Acute ischemic stroke
With cerebral microangiopathy (defined by a SVD score > 1)

Exclusion criteria

Acute hemorrhagic stroke
Anophthalmia

Treatment and study plan

color fundus photography (CFP) and OCT-A

Diagnostic Test

Included patients will have an ophthalmologic assessment (OCT-A and CPF) after stabilization and at 3 months follow-up.

Primary outcomes

Presence of an anomaly in color fundus photography or an anomaly of retinal capillary density to OCT-A

Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: OCTAV

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2022
First posted: May 28, 2019
Registry last updated: Mar 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed