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Completed

NCT Number: NCT02717767

Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU

The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia. In presence of bacterial growth on lung samples, the measure of autofluorescence of white corpuscles could help the clinicians to discriminate bacterial colonization from acute infection.

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Key information

Conditions

Pneumonia Disease Infections Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Infections

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Blois Hospital, Blois, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hospitalization in intensive care units
  • Mechanical ventilation
  • Age > 18 years
  • Collection of a lung sample for bacteriological analysis for the suspicion of a first episode of lung infection.

Exclusion criteria

  • Refuse to participate

Treatment and study plan

Autofluorescence of white corpuscle

Other

Measure of auto-fluorescence of white corpuscles cells harvested from tracheal aspirate and/or bronchoalveolar lavages

Primary outcomes

  1. Pneumonia

    Time frame: 28 days

    Diagnosis of pneumonia (Clinical Pulmonary Infection Score > 6, with assessment of the chest radiography by a blinded investigator)

Secondary outcomes

  1. Clinical Pulmonary Infection Score > 6

    Time frame: day 3

  2. Acute respiratory distress syndrome

    Time frame: day 90

    PaO2/FiO2 < 200 with a PEEP > 5 (Berlin definition)

  3. Duration of mechanical ventilation

    Time frame: day 90

  4. Intensive Care unit Length of stay

    Time frame: day 90

  5. Mortality

    Time frame: day 90

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in Intensive Care Units

Acronym: BIONAGA

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Mar 24, 2016
Registry last updated
Apr 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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