Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.

Acne vulgaris is a common chronic inflammatory disease of the skin. It is found in about 80% of young adults and adolescents. It is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,Oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms that contribute to the development of acne The standard dose of isotretinoin is 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg is effective in the management of acne vulgaris The scope of our study is to detect serum homocysteine level in acne patient befor and after oral isotrtinoin treatment

Inclusion criteria

• Patients of both sexes with acne vulgaris

Exclusion criteria

• Patients with history of malignancies.
• Patients with renal and hepatic dysfunction.
• Cardiac patient.
• Pregnant, lactating and female welling to have pregnancy in the period of study.
• Patient with absorption disorder.
• Patient with history of favism.
• Patient has already been treated with isotretinoin.