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NCT Number: NCT07036315

Meaning in Music-Based Pain Modulation

The overall goal of this project is to examine the impact of music's meaning on pain. Relationships between trait affect, meaning in life, and subjective qualities of meaningful music will be assessed. We will also conduct interviews with a subset of participants to determine which aspects of music are most meaningful and how this meaning increases or decreases pain sensations.

Recruiting

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Virginia

Charlottesville, Virginia, 22903, United States

Location status: Recruiting

Location contact

Patrick Finan, Ph.D.

CONTACT

[email protected]

4349249514

Patrick Finan, Ph.D.

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-65 years old
  • Absence of acute or chronic pain
  • Normal hearing (either naturally or with assistance of hearing device)
  • Must be able to wear an EEG
  • Able to sign consent

Exclusion criteria

  • < 18 or > 65 years old
  • Presence of acute pain (brief pain inventory score > 3)
  • Pregnant women
  • Participant reports that they experience pain on more days than not in the past 6 months (i.e., chronic

Treatment and study plan

Music intervention

Other

Participants will be asked to select different music clips based on meaning, enjoyment and preference.

Primary outcomes

  1. Pain Unpleasantness

    Time frame: Baseline/Pre-intervention and During the Intervention

    Participants will be asked to report pain unpleasantness on a 1 - 100 visual analogue scale ranging from 0 (no sensation) to 100 (intolerable pain)

  2. Pain Intensity

    Time frame: Baseline/Pre-intervention and During the Intervention

    Participants will be asked to report pain intensity on a 1 - 100 visual analogue scale ranging from 0 (no sensation) to 100 (intolerable pain)

Secondary outcomes

  1. The Multidimensional Meaning in Life Scale

    Time frame: Baseline/Pre-intervention

    The multidimensional meaning in life scale is a 16 item validated questionnaire that measures judgments about life's meaning including three subscales of coherence, purpose and mattering. Participants respond to each item using a 7-point Likert scale (1 = Very strongly disagree, 7 = Very strongly agree). A higher score indicates a stronger sense of that dimension of meaning in life.

  2. The Positive and Negative Affect Schedule-X (PANAS-X)

    Time frame: Baseline/Pre-Intervention

    The Positive and Negative Affect Schedule-X (PANAS-X) is a 60-item measure assessing perceived intensity of various emotions, which are aggregated to form positive and negative affect scales, and a series of subscales. Scores are calculated by summing the numerical values of a 5-point Likert type scale (1 = Very slightly or not at all, 5 = extremely) for each item. Higher scores indicate higher levels of the specific affect being measured.

  3. The Hedonic and Eudaimonic Motives for Activities Scale

    Time frame: Baseline/Pre-intervention

    The Hedonic and Eudaimonic Motives for Activities scale is a 9 item survey used to assess how participants typically approach activities in daily life. Participants rate each item on a 7-point Likert type scale (1 = not at all, 7 = very much) with higher scores indicating more hedonic or eudaimonic motives for activities.

  4. The Geneva Emotional Music Scale

    Time frame: During the Intervention

    Participants will be asked to rate their affective responses to each music clip on a 9-point Likert-type scale. Higher scores indicate a greater experience of each emotion measured.

  5. Optional Micro-Phenomenological Interview

    Time frame: Immediately After the Intervention

    The objective of the interview is to gain in-depth data on participants' thoughts and feelings about what makes music meaningful to them and how such meaning relates to their experience of pain.

Study contacts

Contact information is provided by the study sponsor or research team.

Claudia Denoue, MD

CONTACT

[email protected]

4342436744

Sponsors and collaborators

Lead sponsor

University of Virginia

Other

Collaborators

  • National Center for Complementary and Integrative Health (NCCIH)

Registry information

Official study title

An Investigation of the Intersection of Affect and Meaning in Music-Based Pain Modulation

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 25, 2025
Registry last updated
Nov 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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