Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Recurrent Miscarriages Abortion, Habitual Abortion, Spontaneous Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Urogenital Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

St. Mary's Hospital

London, W2 1NY, United Kingdom

About this study

Little is known about reasons for early pregnancy failures. It is believed that some pathology leading to defective implantation of fetus in maternal uterus may lead to recurrent early miscarriages. This project arises from previous work on pre-eclampsia where we found combination of maternal immune genes (KIR) with their ligand (HLA-C) in the fetus was strongly associated with the disease. We will tissue type the fetus, mother and father in cases of unexplained miscarriages. We hope that genetic findings in recurrent miscarriage will lead to new insights, prevention and treatment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Couples with 3 or more unexplained miscarriages

Exclusion criteria

Previous livebirths, parental karyotypic abnormalities, thrombophilic defects, uterine structural abnormalities

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Registry information

Official study title

Combination of Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

Important dates

Study start: 2005
Study completion: 2005
First posted: Sep 16, 2005
Registry last updated: Oct 16, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed