Description of the Uterine Cavity in Patients With Recurrent Miscarriages

To be diagnosed with recurrent miscarriages, a couple might have a child, however experiences three or more miscarriages, primarily this happens during the first trimester.

These miscarriages often needs medical evacuation or a D & C. Surgery or retained tissue increases the risk of complications as infection and/or adhesions, known as asherman syndrome, which may result in subfertility.

Recently chronic infection in the endometrium has been proposed to contribute to the condition, as protocols including treatment with antibiotics have led to birth at term for some of these women.

Using the very minimal invasive office hysteroscopy, the investigators aim to describe the uterine cavity in patients diagnosed with recurrent miscarriages regarding both abnormalities in the endometrium and chromic infection.

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Key information

Conditions

Recurrent Miscarriages Abortion, Habitual Abortion, Spontaneous Disease Attributes Female Urogenital Diseases and Pregnancy Complications Habitual Abortions Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Persistent Infection Pregnancy Complications Urogenital Diseases Uterine Anomalies

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Hvidovre Hospital, Department of Gynecology and Obstetrics

Copenhagen, Hvidovre, 2650, Denmark

About this study

The Unit for Recurrent Pregnancy-loss at Rigshospitalet treats about 300 of couples with recurrent miscarriages a year. Together with the current examination program, the investigators plan to describe the uterine cavity according to abnormalities as septa, adhesions and further the condition for the endometrium regarding infection and hormone receptors. This description will include descriptive office hysteroscopy with biopsies for histologic - and immunohistochemically examinations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Correctly diagnosed with recurrent miscarriages

Exclusion criteria

Known course of the condition

Treatment and study plan

Office hysteroscopy

Other

Diagnostic hysteroscopy with biopsy

Primary outcomes

Description of the Uterine Cavity in Patients With Recurrent Miscarriages

Time frame: 1 year

Observational study describing the uterine cavity in a selected patient group regarding abnormalities
Description of the Uterine Cavity in Patients With Recurrent Miscarriages

Time frame: 1 year

Observational study describing the uterine cavity in a selected patient group regarding chronic infection

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2019
Study completion: 2019
First posted: Apr 21, 2016
Registry last updated: Mar 29, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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