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NCT Number: NCT06581614

Masticatory Performance Evaluation

The purpose of this experiment is to combine research on masticatory efficiency with the reconstructive expertise of the prosthodontics clinic, focusing on implant-supported fixed dentures as the contemporary gold standard for reconstruction. The goal is to investigate the impact of such prosthetic reconstructions on masticatory efficiency. We will invite patients who have lost their second molar and have undergone single-implant-supported fixed denture reconstruction at the Prosthodontics Department of National Taiwan University Hospital to participate in masticatory function tests. The tests will use a new and relatively simple chewing gum, with the aim of enhancing patients' masticatory function through implant reconstruction in a clinical setting, thereby improving patient well-being and understanding of dental implants. On the research side, the study aims to provide guidance for strategies in the reconstruction of masticatory function.

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Key information

Age range

25 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital, Taipei, Taiwan

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About this study

Chewing is one of the important steps in the process of food digestion, and it is crucial for human nutritional intake and oral health. Chewing efficiency relates to the ability to eat and is influenced by many factors, with the key factor being the absence of posterior teeth. According to traditional occlusal theory, the anterior teeth guide and act as a facade, while the posterior teeth provide support and chewing function. The loss of posterior teeth leads to a decrease in chewing efficiency. In 1954, Dr. A. Albert Yurkstas and others proposed that in healthy adults, the loss of the first molar results in a 33% decrease in chewing efficiency; the loss of the second and third molars results in a 44% decrease; and the loss of the first, second, and third molars results in a 78% decrease. This study laid the foundation for understanding how tooth loss leads to decreased chewing efficiency and highlights the goal of prosthodontics to restore dental arches and chewing function to benefit people.

The purpose of this experiment is to combine the study of chewing efficiency with the expertise of prosthodontics in reconstruction, aiming to investigate the impact of contemporary gold-standard artificial implant-supported fixed restorations on chewing efficiency. The study invites patients missing the second molar and those receiving implant-supported fixed prostheses reconstruction in the Department of Prosthodontics at National Taiwan University Hospital. The new and simpler color-changeable chewing gum will be used to test their chewing efficiency. This will explore the importance of implant-supported fixed prostheses in reconstructing chewing function after the loss of the second molar, aiming to improve patient well-being and understanding of dental implants by restoring chewing function through clinical implant reconstruction. In the research field, this study provides guidance for the reconstruction strategies of chewing function

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

For prospective group:

Inclusion criteria

  • Patients who have lost their second molar, are scheduled to undergo single-implant reconstruction at the Prosthodontics Department of National Taiwan University Hospital, and do not have any major physical or mental health conditions.

Exclusion criteria

  • Severe temporomandibular joint disorder
  • Inability to comply with the treatment schedule
  • Inability to cooperate with masticatory function tests
  • Lack of opposing teeth for the implant-supported restoration
  • Patients whose anterior teeth will be included in the prosthetic reconstruction or whose occlusion will undergo significant changes after reconstruction

For retrospective group:

Inclusion criteria

  • Patients who have lost their second molar, have undergone single-implant-supported fixed restoration reconstruction at the Prosthodontics Department of National Taiwan University Hospital, and do not have any major physical or mental health conditions.

Exclusion criteria

  • Implant-supported dentures that cannot be removed or have significant damage
  • Severe temporomandibular joint disorder
  • Inability to comply with the treatment schedule
  • Inability to cooperate with masticatory function tests
  • Lack of opposing teeth for the implant-supported denture

Treatment and study plan

masticatory function test

Diagnostic Test

During the test, participants will be given a piece of chewing gum to assess their masticatory function when the second molar implant-supported fixed denture is in place.

Primary outcomes

  1. the masticatory performance of patients

    Time frame: After second molar implant reconstruction was done(at least 1 month after reconstruction)

    During the test, participants will be given a piece of chewing gum to assess their masticatory function when the second molar implant-supported fixed restoration is in place.

Study contacts

Contact information is provided by the study sponsor or research team.

Yi-Hao Lan, DDS, MS

CONTACT

[email protected]

+886 922901103

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Effect of Implant Supported Fixed Restoration on Masticatory Efficiency in Patients With Second Molar Loss

Acronym: MPE

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Sep 3, 2024
Registry last updated
Nov 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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