Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization

This study aims to evaluate right-left chewing balance and masticatory function in children with Molar-Incisor Hypomineralization (MIH) before and after restorative treatment. MIH is a developmental enamel defect that may cause tooth sensitivity, discomfort during chewing, and functional asymmetry.

Children aged 7 to 12 years with bilateral MIH affecting the first permanent molars will receive glass hybrid restorative treatment. Right-left occlusal force distribution will be assessed using a digital occlusal analysis system. In addition, chewing side preference and chewing balance will be evaluated using a standardized chewing gum protocol. These two assessment methods will be used together to provide complementary information about masticatory function.

Measurements will be performed before treatment and during follow-up visits after treatment. The findings obtained from children with MIH will also be compared with healthy children without MIH. The study aims to determine whether restorative treatment improves chewing balance and functional oral performance in children with MIH.

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Key information

Conditions

Molar-Incisor Hypomineralization (MIH) Chewing Function Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dental Enamel Hypomineralization Developmental Defects of Enamel Masticatory Performance Molar Hypomineralization Occlusal Analysis Stomatognathic Diseases Stomatognathic System Abnormalities Tooth Abnormalities Tooth Diseases

Age range

7 year–13 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children aged 7 to 12 years
Presence of bilateral molar-incisor hypomineralization (MIH) affecting first permanent molars
Need for restorative treatment in MIH-affected molars
Cooperative children with sufficient cognitive ability to complete functional assessments
Presence of healthy control participants without MIH for comparison
Mixed dentition period
Signed informed consent obtained from parents or legal guardians

Exclusion criteria

Temporomandibular disorders or orofacial pain
Systemic diseases or regular medication use affecting mastication
History of orthodontic treatment or parafunctional habits
Craniofacial anomalies or developmental dental anomalies
Extensive prosthetic restorations affecting chewing function
Uncooperative children unable to complete examination procedures
Acute dental infection or pain requiring emergency treatment

Treatment and study plan

Glass Hybrid Restorative Treatment

Procedure

Restorative treatment of MIH-affected molars using glass hybrid restorative material to evaluate changes in occlusal force distribution and chewing function.

Primary outcomes

Percentage of Occlusal Force Distribution Between Right and Left Sides

Time frame: Baseline and 3 months after restorative treatment

Percentage distribution of occlusal force between the right and left sides and chewing side assessed using a chewing gum test will be evaluated before and after restorative treatment in children with MIH using a digital occlusal analysis system.

Study contacts

Contact information is provided by the study sponsor or research team.

Afra Nur Savas

CONTACT

[email protected]

+90 534 327 92 74

Sponsors and collaborators

Lead sponsor

Marmara University

Other

Registry information

Official study title

Evaluation of Occlusal Force Distribution and Masticatory Function Before and After Restorative Treatment in Children With Molar-Incisor Hypomineralization

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: May 15, 2026
Registry last updated: Jun 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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