Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07702825

Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity

The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity. The main question the investigators aim to answer is if there is improvement in organ health with weight loss intervention. The investigators will be comparing the degree of these changes between children being treated with GLP1 receptor agonists in addition to lifestyle changes and those managed with lifestyle changes alone. Participants will undergo MRI body composition at baseline and after 9 months.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Childhood Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pediatric Obesity Signs and Symptoms

Age range

12 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Alder Hey Children's hospital

Liverpool, Merseyside, L122AP, United Kingdom

Location status: Recruiting

Location contact

Anand Ramakrishnan, MBBS, MD, MRCPCH, DipUKMP

CONTACT

[email protected]

07404613764

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 12 to <18 years at the time of enrolment
  • BMI >99.6th centile or >2.67 SDS
  • Informed consent from parent(s) (or person with parental responsibility) and assent from the child or young person for participants aged less than 16 years (or)
  • Informed consent from the participant if aged ≥ 16 years.

Exclusion criteria

  • Body weight above upper limit of the scanner (>250 kilograms)
  • Needs general anaesthesia for the MRI scanning
  • Any contraindications for MRI- Metal implants/claustrophobia
  • Previous use of GLP-1 receptor agonist
  • Refusal to consent or refusal to assent from a competent older adolescent.

Treatment and study plan

Primary outcomes

  1. Change in Liver fat measured using quantitative MRI

    Time frame: From enrollment to 9 months

    Change in liver fat content from baseline to follow-up, quantified using MRI-derived proton density fat fraction (PDFF).

Secondary outcomes

  1. Changes to body composition assessed by MRI

    Time frame: Baseline to 9 months

    Change from baseline in Visceral adipose tissue(VAT) and Subcutaneous adipose tissue (VAT) measured in cm2 assessed by quantitative MRI

  2. Change in pancreatic fat assessed by MRI.

    Time frame: Baseline to 9 months

    Change from baseline in pancreatic fat measured as proton density fat fraction (%) assessed by quantitative MRI.

  3. Changes in biochemical parameters-fasting glucose

    Time frame: 9 months

    Changes from baseline in fasting glucose measured in mmol/l

  4. Changes in biochemical parameters-HbA1C

    Time frame: 9 months

    Change from baseline in HbA1C measured in mmol/mol

Other outcomes

  1. Change in sleep study parameter

    Time frame: 9 months

    Change in Apnoea Hypopnoea Index (AHI) score from baseline measured as number of events per hour.

Study contacts

Contact information is provided by the study sponsor or research team.

Anand Ramakrishnan, MBBS, MD, MRCPCH, DipUKMP

CONTACT

[email protected]

07404613764

Anand Ramakrishnan, MD (Ped), MSc (Diab), PhD endo

CONTACT

[email protected]

+44 01512525956

Sponsors and collaborators

Lead sponsor

Alder Hey Children's NHS Foundation Trust

Other

Registry information

Official study title

Impact of Weight Loss Interventions on Multiorgan Health, Detected by Quantitative MRI, in Children and Young People With Severe Obesity.

Acronym: FIT-YOUNG

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Jul 14, 2026
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.