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Completed

NCT Number: NCT04544163

Magnesium Versus High Dose Fentanyl in Endotracheal Intubation

this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation

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Key information

Conditions

Stress Response Fractures, Bone Fractures, Stress Wounds and Injuries

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Walaa Y Elsabeeny

Cairo, 11796, Egypt

About this study

to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation
  • ASA I II
  • 18 to 60

Exclusion criteria

  • allergy to any of the used drugs
  • renal or hepatic impairment
  • hypertensive patients, patients with cardiovascular or cerebrovascular diseases

Treatment and study plan

Magnesium sulfate- Fentanyl

Drug

drug administration before intubation

Other names: MgSo4

Fentanyl 4Mcg/kg

Drug

drug administration with induction of anesthesia

Other names: high dose fentanyl

Fentanyl 2Mcg/kg

Drug

drug administration with induction of anesthesia

Other names: Conventional anesthesia

Lidocaine 1.5 mg/kg

Drug

drug administaration 90 sec before intubation

Other names: Lidocaine

Primary outcomes

  1. heart rate values

    Time frame: 5 minutes

    changes in heart rate values after intubation

Secondary outcomes

  1. blood pressure

    Time frame: 5 minutes

    mean arterial blood pressure values

  2. coughing during intubation

    Time frame: lntubation time

    coughing during intubation

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Official study title

Magnesium Versus High Dose Fentanyl in Attenuating Stress Response to Endotracheal Intubation

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Sep 10, 2020
Registry last updated
May 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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