Lung Scintigraphy for Pulmonary Embolism Diagnosis in COVID-19 Patients.

A frequent complication of COVID-19 disease is pulmonary embolism (PE).

Lung ventilation/perfusion (V/P) scintigraphy is a well-established test for PE diagnosis. The test is interpreted based on the recognition of wedge shaped perfusion mismatched defects. However, the ventilation procedure increases the potential risk of contamination by the aerosol secretion and the expired air.

A variety of strategies have been proposed in the nuclear medicine literature regarding performance of lung ventilation scintigraphy in COVID-19 patients with suspected acute PE. However, there is currently no factual data in this specific population to support recommendations to the nuclear medicine community.

The aim of this study was to assess the role of ventilation imaging when performing lung scintigraphy for suspected PE in COVID-19 patients.

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Key information

Conditions

Pulmonary Embolism COVID-19 Cardiovascular Diseases Coronaviridae Infections Coronavirus Infections Embolism Embolism and Thrombosis Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Vascular Diseases Virus Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Brest, Brest, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with suspected COVID-19 disease
Referred for lung scintigraphy for suspected acute PE

Exclusion criteria

Patient under guardianship or curatorship
Patient deprived of liberty by an administrative or judicial decision
Inability or refuse to give consent

Treatment and study plan

Primary outcomes

PE diagnosis on lung scintigraphy without the ventilation scan.

Time frame: 1 day

Percentage of scans for which the diagnostic conclusion of the lung scan would have been different when omitting the ventilation scan

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Lung Scintigraphy for Pulmonary Embolism Diagnosis in COVID-19 Patients: a Multicenter Observational Study.

Acronym: SCINTI-COVID

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: Apr 29, 2022
Registry last updated: Aug 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed