Risk of Venous Thromboembolism in Critically Ill Patients With Severe COVID-19

Severe COVID-19 patients at a high risk of venous thromboembolism. We studied patients in 2 intensive care units of university hospitals in Barcelona and Badalona, Spain. We performed a cut-off screening of deep venous thrombosis (DVT) with bilateral duplex ultrasound to 230 patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

COVID-19 Cardiovascular Diseases Coronaviridae Infections Coronavirus Infections Critical Illness Disease Attributes Embolism Embolism and Thrombosis Infections Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Pulmonary Embolism Pulmonary Embolism and Thrombosis RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections SARS-CoV Infection Sars-CoV2 Severe Acute Respiratory Syndrome Thromboembolism Thrombosis Vascular Diseases Venous Thromboembolism Venous Thromboses Venous Thromboses, Deep Venous Thrombosis Venous Thrombosis Pulmonary Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Vall d´Hebron Research Institute VHIR, Barcelona, Catalonia, Spain

About this study

SARS-CoV-2 infection has been associated with coagulation disorders and increased risk of venous thromboembolism (VTE). The aim of the study is to determine the cumulative incidence of VTE in critically ill patients with COVID-19 and its impact on prognosis.

Methods Cohort study of critically ill patients due to COVID-19. A bilateral venous compression (CUS) ultrasound screening of the lower extremities was performed during a cut-off period in 2 intensive care units of university hospitals in Spain. Asymptomatic and symptomatic VTE were registered: pulmonary embolism (PE) (diagnosed by CT-angiography) and deep venous thrombosis (DVT). The characteristics of the patients, results of their blood tests and their evolution after 7 days of follow-up were recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with severe COVID-19 pneumonia admitted to the intensive care unit

Exclusion criteria

Treatment with Extracorporeal membrane oxygenation (ECMO)
Pregnant or postpartum women
Under 18 years old

Treatment and study plan

Duplex ultrasound and Computed Tomography Angiography

Diagnostic Test

All venous thromboembolisms suspected will diagnosed with ultrasound and CT-angiography

Other names: Compression ultrasound (CUS), Ct-Angiography

Primary outcomes

Venous thromboembolisms

Time frame: 7 days

Patients with symptomatic pulmonary embolism confirmed on the CT-angiography and those with a swollen limb and confirmed deep venous thrombosis on compression ultrasound were considered to have "symptomatic venous thromboembolisms". The remaining patients with positive limb ultrasound or CT-angiography were considered to have "asymptomatic venous thrombembolism"

Secondary outcomes

Deaths

Time frame: 7 days

Deaths from all causes during the follow-up

Sponsors and collaborators

Lead sponsor

Hospital Universitari Vall d'Hebron Research Institute

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: May 5, 2020
Registry last updated: May 6, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed