Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07040735

Low-Flow Anesthesia and Open-Heart Surgery

Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L/min. In 1984, Baker and Simionescu classified LFA as 0.5-1 L/min and MFA as 0.25-0.5 L/min. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Low-flow Anesthesia Hemodynamics Open-heart Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Gazi University Faculty of Medicine

Ankara, Turkey (Türkiye)

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-≥18 years and scheduled for open-heart surgery patients

-ASA I-II-III-IV physical class

Exclusion criteria

  • Emergency cases
  • Patients under 18 years of age
  • Patients who have had open heart surgery before
  • Patients for whom the use of inhaled anesthetic agents is contraindicated
  • Patients who do not sign a voluntary consent form

Treatment and study plan

Primary outcomes

  1. physiological parameter ; heart rate

    Time frame: Intraoperatively

    Heart rate will be recorded every 10 minutes, expressed as beats per minute, starting before induction and including the sternotomy and pericardiotomy periods.

  2. physiological parameter; systolic/diastolic blood pressure

    Time frame: Intraoperatively

    Systolic and diastolic blood pressure will be recorded every 10 minutes in mmHg, starting before induction and including the sternotomy and pericardiotomy periods.

  3. physiological parameter; SpO2

    Time frame: Intraoperatively

    SpO2 will be recorded as a percentage every 10 minutes, starting before induction and including the sternotomy and pericardiotomy periods.

  4. Monitoring parameter; Bispectral Index (BIS)

    Time frame: Intraoperatively

    The BIS value will be recorded numerically every 10 minutes, starting from before induction and including the sternotomy and pericardiotomy periods.

  5. Monitoring parameter; Minimum alveolar concentration (MAC)

    Time frame: Intraoperatively

    The MAC value will be recorded numerically every 10 minutes, starting from before induction and including the sternotomy and pericardiotomy periods.

Secondary outcomes

  1. Preoperative data; ASA (American Society of Anesthesiologists) classification

    Time frame: 24 hours before surgery

    During the preoperative period, preoperative data, including the American Society of Anesthesiologists (ASA) Physical Status Classification, will be recorded. The ASA classification is used to assess the patient's preoperative physical status and perioperative risk, with higher ASA classes (I-IV) indicating increased systemic disease severity and perioperative risk.

  2. Preoperative data

    Time frame: 24 hours before surgery

    In the preoperative period, the degree of valve dysfunction (such as I.degree TY, II.degree MY) of the patients will be recorded.

  3. Preoperaitive data

    Time frame: 24 hours before surgery

    In the preoperative period, the patient's ejection fraction will be recorded as a percentage.

Study contacts

Contact information is provided by the study sponsor or research team.

Çağrı Özdemir

CONTACT

[email protected]

+905544239196

Sponsors and collaborators

Lead sponsor

Çağrı Özdemir

Other

Registry information

Official study title

The Effect of Low-Flow Anesthesia on Hemodynamics in Open-Heart Surgery

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 27, 2025
Registry last updated
May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.