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Completed

NCT Number: NCT01096836

Low Carbohydrate and Conventional Diets Associated to Resistance Training on Muscle Fitness and Health Markers

The purpose of this study was to compare the effects of two different diets (low carbohydrate - LCD and conventional - CONV) on body composition, strength performance, muscle mass and biomarkers of health in overweight adults submitted to resistance training (RT). It has been hypothesized that LCD would produce higher rates of weight loss and that both diets would be useful to maintain muscle mass and strength and biomarkers of health.

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Key information

Conditions

Obesity Body Weight Hypertrophy Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Laboratory Crossbridges

Rio de Janeiro, 20748-900, Brazil

About this study

Overweight and obesity prevalence has increased worldwide. Current guidelines recommend health behavior modifications, including better eating habits and regular physical activity (including resistance training - RT) as a strategy to control and prevent the problem. Traditionally, diets poor in energy and fat (conventional diets - CONV) have been recommended to promote losses in body and fat masses; however, there has been recently a growing interest in the academic community to investigate the effects of low carbohydrate diet (LCD) on health outcomes, since this kind of diet appears to be more effective for reducing body mass as compared to CONV. Nevertheless, evidences are scarce regarding the effects of LCD associated to RT on body composition, strength performance, blood lipids, endothelium function and other markers of health, demanding the development of clinical trials aiming to determine the combined health effects of these interventions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI equal or over 25 kg/m2
  • resistance trained at least 12 weeks

Exclusion criteria

  • upper or lower limbs injury
  • pregnancy
  • diabetes
  • use of ergogenics, stimulants or drugs
  • history of dislipidemias
  • arterial hypertension

Treatment and study plan

macronutrient and energy manipulation

Other

Primary outcomes

  1. body mass

    Time frame: eight weeks

    Measured always at the same time of the day on a calibrated weight scale

Secondary outcomes

  1. Muscle strength

    Time frame: eight weeks

    Measured using resistance exercise machines (isotonic) in four exercise movements

  2. Endothelial function

    Time frame: eight weeks

    Measured using a two dimensional color spectral Doppler ultrasound equipped with a 14MHz linear transducer. Subject laid down comfortably in the supine position with the right arm slightly abduced. After locating the brachial artery, the transducer was placed on the anteromedial face of the right arm, perpendicular to the centerline of the arm, 5-10 cm above the antecubital fossa, over the artery.

  3. muscle thicknesses

    Time frame: eight weeks

    Measured with a ultrasoundo bidimensional in Mode B, with a 7,5MHz transducer on the anatomical sites knee extensor muscles and elbow flexors and extensors.

  4. markers of renal function

    Time frame: eight weeks

    Measured using conventional and satandardized laboratory methods with subjects fasting for 12 hours

  5. body composition

    Time frame: eight weeks

    Measured with skinfold calipers and using prediction equations to determine body fat and lean body mass.

Sponsors and collaborators

Lead sponsor

Universidade Gama Filho

Other

Registry information

Official study title

Combined Effects of Resistance Training and Low Carbohydrate or Conventional Diets on Strength, Muscle Mass, Body Composition, Blood Lipids and Endothelium Function

Acronym: LCD-RT

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
Mar 31, 2010
Registry last updated
Mar 31, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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