Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin

The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.

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Key information

Conditions

Spinal Cord Diseases Central Nervous System Diseases Nervous System Diseases Spinal Cord Injuries Trauma, Nervous System Wounds and Injuries

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

BioMag laboratory

Helsinki, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

incomplete SCI of non-traumatic origin

Exclusion criteria

epilepsy
metal inclusion in the head area
pacemaker
hearing device
high intracranial pressure

Treatment and study plan

long-term paired associative stimulation

Device

Paired associative stimulation (PAS) administered several times per week for 6 weeks to one hand. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).

Primary outcomes

Daniels and Worthingham's Muscle Testing

Time frame: 2 days after the last stimulation session

each hand muscle is evaluated on 0-5 scale
Daniels and Worthingham's Muscle Testing

Time frame: 1 month after the last stimulation session

each hand muscle is evaluated on 0-5 scale

Sponsors and collaborators

Lead sponsor

Helsinki University Central Hospital

Other

Collaborators

University of Helsinki
Validia Rehabilitation Center

Registry information

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Apr 7, 2017
Registry last updated: Sep 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed