Long Term Effects On Recipients of Hematopoietic Stem Cell Transplantation

Primary Objective: Implement long-term follow-up guidelines for children, adolescents and young adults who are survivors of HSCT while establishing a database which captures the survivor's lifetime care.

Secondary Objectives:

• Collect evidence-based data through a structured framework of periodic physical examination, laboratory and medical tests to monitor late effects in our HSCT survivors.
• Establish standards of care for late effects of therapy post HSCT for malignant and non-malignant diagnoses.
• Provide early identification and intervention towards recognized problems, as well as consistent education to foster a healthy lifestyle to all survivors.
• Collect blood and tissue samples to study immune reconstitution of all immune cell types and learn more about immune reconstitution and its affect on post-HSCT complications and disease free survival.

Inclusion criteria

• Participant is scheduled to receive OR has received a hematopoietic stem cell transplant (HSCT) for any condition.
• Participant may have had a HSCT in another institution than Lucile Packard Children's Hospital (LPCH) yet has transferred follow-up long-term care to our institution and is being seen through the late-effects clinic from the Pediatric HSCT program.
• Participant AND/OR parent/legally authorized representative is able to provide written informed consent and assent (as applicable) for participation.

Exclusion criteria

• Participant has relapsed from a malignant diagnosis post HSCT and is not being worked-up for a new HSCT.
• Participant or patient's authorized guardian is unable to provide consent and assent