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OpenTrials
Completed

NCT Number: NCT01256840

Long-term Caloric Restriction and Cellular Aging Markers

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

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Key information

Conditions

Aging

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California

San Francisco, California, 94118, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Calorie restricting group: Self-reported caloric restriction for at least two years
  • Calorie restriction group: BMI below 23
  • Normal eating control: Normal eating (no history of caloric restriction) for two years
  • Normal eating control: BMI below 30
  • Obese comparison group: BMI above 30
  • Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion criteria

  • Regular smoker for the past six months

Treatment and study plan

Primary outcomes

  1. Telomere Length

    Time frame: One day

    This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Collaborators

  • Robert Wood Johnson Foundation

Registry information

Official study title

Caloric Restriction With Optimal Nutrition and Aging Study

Acronym: CRONA

Important dates

Study start
2010
Primary completion
2014
Study completion
2014
First posted
Dec 9, 2010
Registry last updated
Oct 13, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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