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NCT Number: NCT07633379

Local Field Potential Correlates of Neuropsychiatric Symptoms in Parkinson's Disease

This prospective observational cohort study aims to investigate whether intracranial Local Field Potentials (LFPs) recorded from implanted Deep Brain Stimulation (DBS) devices are associated with neuropsychiatric symptoms in people with Parkinson's disease (PD). The study will focus on paroxysmal anxiety, impulse control disorders, and hallucinations.

Twenty participants with Parkinson's disease and an implanted Medtronic Percept DBS device will be recruited. Participants will complete behavioural and clinical assessments and will use the event-marking functionality of the DBS device to record symptom episodes over a monitoring period of approximately 120 days. Brain activity will be passively recorded during this period.

The study will evaluate relationships between LFP signals, symptom occurrence, behavioural task performance, and clinical symptom severity measures. Machine learning approaches will be used to identify electrophysiological patterns associated with neuropsychiatric symptom states at an individual level.

The findings may improve understanding of the neural mechanisms underlying neuropsychiatric symptoms in Parkinson's disease and support the future development of personalised adaptive neuromodulation approaches.

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Key information

Conditions

PARKINSON DISEASE (Disorder) Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ruijin Hospital, Shanghai, China

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • A diagnosis of Parkinson's Disease
  • A diagnosis of hallucinations, impulse control disorder, or panic disorder (episodic anxiety)
  • Previous bilateral DBS implantation with a Medtronic Percept device as part of clinical care

Exclusion criteria

  • Non-English speakers
  • <18 years old or >75 years old
  • A history of concurrent conditions that could significantly confound the study results, such as other significant neurological condition (e.g., brain injury/infection, substance abuse) or concurrent severe psychiatric condition (e.g., schizophrenia)
  • Moderate/severe Intellectual Disability or inability to understand study procedures
  • Lack of capacity to consent to the study
  • Currently involvement in other studies

Treatment and study plan

Primary outcomes

  1. Identification of Local Field Potential Correlates of Neuropsychiatric Symptoms in Parkinson's Disease

    Time frame: Baseline through Day 120

    Association between intracranial Local Field Potential (LFP) recordings from the Medtronic Percept Deep Brain Stimulation device and participant-reported neuropsychiatric symptom events, including hallucinations, impulse control symptoms, and episodic anxiety. Machine learning approaches will be used to identify electrophysiological patterns associated with symptom states.

Secondary outcomes

  1. Temporal Dynamics of Neuropsychiatric Symptoms

    Time frame: Baseline through Day 120

    Characterisation of the frequency, timing, and temporal patterns of participant-reported neuropsychiatric symptom events recorded using the Medtronic Percept device event-marking function.

  2. Association Between LFP Features and Behavioural Task Performance

    Time frame: Baseline assessment at Day 0

    Association between Local Field Potential (LFP) features and performance on reward-processing behavioural tasks, including the Monetary Incentive Delay task and Apple Gathering Task.

  3. Association Between LFP Features and Clinical Symptom Severity Measures

    Time frame: Baseline assessment at Day 0

    Association between Local Field Potential (LFP) features and validated clinical symptom severity scales, including the Neuropsychiatric Inventory (NPI), Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale (QUIP-RS), and Parkinson Anxiety Scale (PAS).

Study contacts

Contact information is provided by the study sponsor or research team.

Paul Shotbolt, PhD

CONTACT

[email protected]

+4402078365454

Sponsors and collaborators

Lead sponsor

King's College London

Other

Collaborators

  • Ruijin Hospital

Registry information

Official study title

Intracranial Local Field Potential (LFP) Correlates of Neuropsychiatric Symptoms in Parkinson's Disease

Acronym: LFP-in-PD

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jun 8, 2026
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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