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NCT Number: NCT06491628

Liver Function Abnormalities in Patients With Acute Heart Failure

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

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Key information

Conditions

Acute Heart Failure Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Coagulation Protein Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemophilia A Hemorrhagic Disorders

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag university

Sohag, Egypt

About this study

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure.

The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF.

Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged 18 yrs or older presenting with AHF

Exclusion criteria

  • Congenital heart disease
  • acute and chronic liver diseases

Treatment and study plan

Avoiding the risk factors

Behavioral

Exercise, Salt and lipid reduction in diet, smoking cessation

Primary outcomes

  1. Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals

    Time frame: baseline

    assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Secondary outcomes

  1. Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals

    Time frame: 1 year

    assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Study contacts

Contact information is provided by the study sponsor or research team.

Hassan Ahmed

CONTACT

+201003459741

Sara Mohamed

CONTACT

[email protected]

+201117517685

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Liver Function Abnormalities in Patients With Acute Heart Failure in Sohag University Hospitals

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 9, 2024
Registry last updated
Jul 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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