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NCT Number: NCT06009289

Light and Sleep Fragmentation

This trial will examine scheduled exposure to bright light in the morning and afternoon as a countermeasure to sleep fragmentation in older individuals with mild cognitive impairment.

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Key information

Conditions

Sleep Cognition Disorders Cognitive Dysfunction Mental Disorders Mild Cognitive Impairment Mood Disorders Neurocognitive Disorders

Age range

65 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Stanford University

Redwood City, California, 94063, United States

Location contact

Renske Lok, PhD

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mild Cognitive Impairment
  • Age >65

Exclusion criteria

  • Severe depression
  • Unstable psychiatric or medical disease
  • Acute infection

Treatment and study plan

Light therapy

Behavioral

One hour of exposure to bright light, either by being outdoors or with a phototherapy lamp if indoor

Primary outcomes

  1. Sleep fragmentation

    Time frame: 4 weeks

    24 hour sleep wake patterns will be quantitated with a non-parametric measure, intradaily variation

Secondary outcomes

  1. Cognition

    Time frame: 6 months

    Performance on the WAIS-4

  2. Mood

    Time frame: 6 months

    Geriatric Depression Scale, range: 0-15 with higher scores being associated with greater depressive symptomatology

Study contacts

Contact information is provided by the study sponsor or research team.

Renske Lok, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Official study title

Application of Precision Medicine to Phototherapy: a Stepped Care Approach to Consolidate Sleep and Slow Cognitive Decline in Older Adults

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Aug 24, 2023
Registry last updated
Aug 25, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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