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NCT Number: NCT03708952

Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases

The association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear. This study is conducted in Jinhua, a city with a high prevalence of colorectal cancer in China, to assess the relationship between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Polyps Cardiovascular Diseases Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

45 year–74 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Lanxi Hospital of Traditional Chinese Medicine, Jinhua, Zhejiang, China

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About this study

Investigations of lifestyle and dietary factors in relation to precursor lesions of colorectal cancer and cardiometabolic diseases are limited in China. The investigators aim to collect the basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors and so on, to assess the associations between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases. This large cohort - the Lanxi Pre-colorectal Cancer Cohort (LP3C) also included several subcohorts consisting of patients with CVD, diabetes, hypertension, metabolic syndrome, obese/overweight or fatty liver disease. Results from this study will be valuable for colorectal cancer and cardiometabolic disease prevention in China.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject aged ≥45 and ≤74 years old
  • Subject has complete data on diet and follow-up time

Exclusion criteria

  • Colorectal cancer
  • Severe intestines problems

Treatment and study plan

Primary outcomes

  1. Numbers of participants with polyps

    Time frame: From entry into the study (baseline:2018-2022) until 2028

    All polyps

Secondary outcomes

  1. Numbers of participants with different subtypes of polyps

    Time frame: From entry into the study (baseline:2018-2022) until 2028

    Subtypes of polyps, including serrated polyps, hyperplastic polyps, sessile serrated polyps/adenoma

  2. Numbers of participants with cardiometabolic diseases

    Time frame: From entry into the study (baseline:2018-2022) until 2028

    Cardiometabolic diseases including cardiovascular disease, diabetes, and hypertension

Other outcomes

  1. Numbers of participants died

    Time frame: From entry into the study (baseline:2018-2022) until 2028

    All-cause and cause-specific mortality outcomes

Sponsors and collaborators

Lead sponsor

Zhejiang University

Other

Collaborators

  • Lanxi Hospital of Traditional Chinese Medicine
  • Lanxi Red Cross Hospital

Registry information

Official study title

Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases Among High-risk Populations in Lanxi, China

Important dates

Study start
2018
Primary completion
2024
Study completion
2028
First posted
Oct 17, 2018
Registry last updated
Jan 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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