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NCT Number: NCT05884697

Let's K-Talk - HPV Study for Ethnic Koreans

The goal of this clinical trial is to test the feasibility, acceptability, and preliminary efficacy of a storytelling video-based intervention using AI chatbot technology (K-Talk) to promote HPV vaccination behavior among Korean Americans aged 18 to 45.

The main questions this study aims to answer are:

* Is the K-Talk intervention feasible for use among Korean Americans aged 18 to 45? * Is the K-Talk intervention acceptable to the target population? * What is the preliminary efficacy of the K-Talk intervention in promoting HPV vaccination uptake?

Participants will be Korean Americans aged 18 to 45 who are at risk for HPV infection. Participants will be asked to complete a baseline survey and then will be "randomized" into one of four groups: Group 1 (chatbot + storytelling intervention), Group 2 (chatbot only), Group 3 (storytelling only), and Group 4 will be only exposed to written didactic HPV education materials. All groups will receive written didactic HPV education materials. Researchers will compare how Group 1, a combination of AI Chatbot and storytelling intervention is more effective than other intervention groups in promoting HPV vaccination uptake among underserved, hard-to-reach Korean Americans.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Human Papillomavirus Viruses Papillomavirus Vaccines

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Minjin Kim

Cincinnati, Ohio, 45221-0038, United States

About this study

The objective of this study is to conduct a pilot Multiphase Optimization Strategy trial (MOST) to evaluate the acceptability, feasibility, and preliminary efficacy of K-Talk as an intervention to improve HPV vaccination initiation and completion among Korean American men and women. K-Talk is a user-centered intervention that combines AI chatbot technology with storytelling to enhance health communication, foster connection, and provide accurate advice related to HPV vaccination. The study design follows an optimization phase of the MOST, utilizing a 2 x 2 factorial design with two factors (storytelling and chatbot) and two levels (Yes/On and No/Off). The study aims to recruit a total of 160 participants, with 40 participants assigned to each experimental condition. The sample will consist of 80 males and 80 females who are eligible for participation in factorial experimentation using the MOST design. Interested individuals will undergo an online eligibility screening survey. If eligible for the study, participants will receive an online survey link containing informed consent, a baseline survey, written HPV information, and random assignment to an intervention group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Identify as a Korean ethnic person
  • Reside in the U.S.
  • between the ages of 18 and 45
  • be able to speak or read English
  • not have been vaccinated against HPV
  • use a mobile device.

Exclusion criteria

  • Participants who do not identify as a Korean ethnic person
  • Participants who do not reside in the U.S.
  • Participants who are not between the ages of 18 and 45.
  • Participants who cannot speak or read English.
  • Participants who have been vaccinated against HPV.
  • Participants who do not use a mobile device.

Treatment and study plan

K-Talk Intervention (Storytelling and K-Bot)

Other

The K-Talk intervention group receives a combination of a storytelling intervention and an artificial intelligence chatbot (K-Bot) education.

Storytelling Intervention

Other

The storytelling intervention features 12 authentic stories from young Korean immigrants and Americans. Each video is about 3 minutes long and includes stories from 1st, 1.5, and 2nd generation young Korean individuals, highlighting their perceptions of HPV and HPV vaccines, and their experiences with HPV vaccination.

K-Bot Intervention

Other

The K-Bot intervention is a conversational and button-based artificial intelligence Chatbot that is available in both English and Korean.

Written information

Other

The written information provided includes the Centers for Disease Control and Prevention's (CDC) details on HPV and HPV vaccines.

Primary outcomes

  1. Number of participants who completed 3 doses of HPV vaccines at 12-months

    Time frame: 12 months after the baseline

    Completion of 3 doses of HPV vaccines

  2. Number of participants who completed 3 doses of HPV vaccines at 6-months

    Time frame: 6 months after the baseline

    Completion of 3 doses of HPV vaccines

  3. Number of participants who received at least one dose of HPV vaccine at 3-month

    Time frame: 3-months after the baseline

    Participants who received at least one dose of HPV vaccine at 3-month

  4. Number of participants who received at least one dose of HPV vaccine at 6-month

    Time frame: 6-months after the baseline

    Participants who received at least one dose of HPV vaccine at 6-month

  5. Number of participants who received at least one dose of HPV vaccine at 12-month

    Time frame: 12-months after the baseline

    Participants who received at least one dose of HPV vaccine at 12-month

Secondary outcomes

  1. Assessment of Knowledge about HPV and HPV Vaccines: A 34-Item Survey (True/False/I don't know)

    Time frame: at baseline and 3-month follow-up

    Higher scores represent better knowledge.

  2. Assessing Perceived Risk of HPV and Other STIs: A 17-Item Survey (on a 1-5 Likert scale)

    Time frame: at baseline and 3-month follow-up

    Higher scores indicate higher risk perceptions about HPV and STI

  3. Assessment of Intention to Receive HPV Vaccine: Two Items Self-Report

    Time frame: at baseline, 3-month, 6-month, and 12-month follow-up

    Two questions will be used to assess participants' intention to receive HPV vaccines: "Do you intend to get the HPV vaccine?" and "How likely is it that you will get an HPV vaccine in the next 3 months?"

Sponsors and collaborators

Lead sponsor

University of Cincinnati

Other

Registry information

Official study title

Let's K-Talk: A Storytelling Intervention Leveraging Chatbot Technology to Prevent HPV and HPV Associated Cancers for Ethnic Koreans Living in the U.S.

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jun 1, 2023
Registry last updated
Aug 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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