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OpenTrials
Active, Not Recruiting

NCT Number: NCT05148559

Impact of Adolescent Vaccine Reminder Notices Sent Via Preferred Method of Communication on HPV Vaccination

Vaccine uptake in the United States is lower in rural areas, especially for HPV vaccine. Reminder/recall has been identified as an effective strategy to increase vaccination rates. This study will assess the impact by rurality of vaccine reminder notices sent via the parent's preferred method of communication on HPV vaccination among 12 year-old patients in a regional healthcare system.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Papillomavirus Vaccines

Age range

12 year–12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Marshfield Clinic Health System

Marshfield, Wisconsin, 54449, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Marshfield Clinic Health System patient aged 12 years with at least one preventive visit or two evaluation & management visits with a Marshfield Clinic Health System provider in the last 36 months
  • Due for at least one adolescent vaccine (HPV, MenACWY, Tdap)

Exclusion criteria

  • Primary care provider is not affiliated with Marshfield Clinic Health System
  • Opted out of Marshfield Clinic Health System vaccine reminder notifications
  • Missing or invalid contact information
  • Deceased

Treatment and study plan

Reminder Sent Via Preferred Method of Communication

Behavioral

Parents of 12 year-old patients due for ≥1 adolescent vaccine will receive a vaccine reminder notice every other month via their preferred method of communication (text message, email, mailed letter) until the adolescent receives all recommended vaccines, opts out of reminders, or turns 13.

Reminder Sent Via Mailed Letter

Behavioral

Parents of 12 year-old patients due for ≥1 adolescent vaccine will receive a mailed vaccine reminder letter every other month until the adolescent receives all recommended vaccines, opts out of reminders, or turns 13.

Primary outcomes

  1. Number of patients that received 1 dose of HPV vaccine during follow-up based on electronic health data

    Time frame: 90 days

    Receipt of 1 dose of HPV vaccine within 90 days of receipt of reminder (yes/no) will be assessed using vaccination data available from the Marshfield Clinic Health System electronic health record, which includes vaccinations administered outside of MCHS through data exchanges with the Wisconsin Immunization Registry. Specifically patients will be classified as having received 1 dose of HPV vaccine if they have record of receipt of HPV vaccine with a vaccination date during the 90-day follow-up period.

Sponsors and collaborators

Lead sponsor

Huong Nguyen, PhD

Other

Collaborators

  • Centers for Disease Control and Prevention

Registry information

Official study title

Understanding and Addressing the Disparity in Vaccination Coverage Among U.S. Adolescents Living in Rural Versus Urban Areas

Important dates

Study start
2021
Primary completion
2022
Study completion
2026
First posted
Dec 8, 2021
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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