Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07666061

Laser vs Lontophoresis in KOA

This randomized controlled trial aims to compare the effectiveness of laser therapy and iontophoresis in patients with knee osteoarthritis. The study will evaluate pain reduction, functional improvement, and knee joint mobility following

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Knee Arthritis Osteoarthritis

Age range

45 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Participants will be randomly assigned into three groups receiving either laser therapy plus conventional physiotherapy, iontophoresis plus conventional physiotherapy, or conventional physiotherapy alone. Outcome measures will be assessed before and after treatment

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • * Age 45-65 years.
  • Diagnosed primary knee osteoarthritis (Grade I-II).
  • Both genders.
  • Ability to follow treatment protocol.

Exclusion criteria

  • * Previous knee surgery.
  • Intra-articular injections within last 6 months.
  • Pacemaker.
  • Skin lesions at treatment area.
  • Severe neurological or cardiovascular disorders.

Treatment and study plan

Low-Level Laser Therapy

Device

Low-level laser therapy combined with conventional physical therapy for patients with knee osteoarthritis to reduce pain and improve functional mobility and knee joint range of motion

Iontophoresis

Device

Iontophoresis using dexamethasone combined with conventional physical therapy for patients with knee osteoarthritis to reduce pain and improve physical function and knee joint mobility

Conventional Physical Therapy Only

Other

Conventional physical therapy program for patients with knee osteoarthritis including therapeutic exercises, stretching, strengthening exercises, and pain relief modalities to improve knee function and mobility.

Primary outcomes

  1. Pain intensity measured using Visual Analogue Scale (VAS)

    Time frame: Baseline and after 4 weeks of treatment

  2. Functional disability measured using WOMAC.

    Time frame: Baseline and after 4 weeks of treatment

  3. 3. Knee Range of Motion (ROM).

    Time frame: Baseline and after 4 weeks of treatment

Secondary outcomes

  1. Change in physical function assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale

    Time frame: Baseline (Day 0) and Week 4

    The WOMAC Physical Function Subscale consists of 17 items assessing difficulty in performing daily activities. Scores range from 0 to 68, with higher scores indicating worse physical function.

  2. 2. Reduction of joint stiffness.

    Time frame: Baseline and after 4 weeks of treatment

  3. Change in daily activities performance assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale

    Time frame: Baseline (Day 0) and Week 4

    The WOMAC Physical Function Subscale consists of 17 items assessing difficulty in activities of daily living. Scores range from 0 to 68, with higher scores indicating worse functional limitation.

Study contacts

Contact information is provided by the study sponsor or research team.

abdulaziz fahad alsulaimani, MASTER

CONTACT

[email protected]

966566613748

Sponsors and collaborators

Lead sponsor

Kafrelsheikh University

Other

Registry information

Official study title

Effectiveness of Laser Therapy Versus Lontophoresis in the Management of Knee Osteoarthritis: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Jun 24, 2026
Registry last updated
Jun 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.