Skip to main content
OpenTrials
Completed

NCT Number: NCT00114725

Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection

Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF). Laser-assisted ICSI differs from conventional ICSI in that a laser is used to drill a small hole through the hard outer coating surrounding an egg before the injection needle containing a single sperm is inserted into the egg. The hole eliminates compression of the egg that normally occurs with conventional ICSI, and thus may reduce the chance of damage. Laser-assisted ICSI is hypothesized to result in increased egg survival, and perhaps improved embryo quality, compared to conventional ICSI.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Infertility Genital Diseases Genital Diseases, Male Infertility, Male Male Urogenital Diseases Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shady Grove Fertility Reproductive Science Center

Rockville, Maryland, 20850, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of infertility
  • Scheduled for IVF with ICSI

Exclusion criteria

  • Retrieval of fewer than 6 mature oocytes

Treatment and study plan

Laser-assisted intracytoplasmic sperm injection

Procedure

Primary outcomes

  1. oocyte survival rate 1 day after ICSI

Secondary outcomes

  1. normal fertilization rate 1 day after ICSI

  2. embryo cell numbers 2 and 3 days after ICSI

  3. embryo fragmentation rates 2 and 3 days after ICSI

  4. embryo compaction rate through day 7 after ICSI

  5. blastocyst formation rate through day 7 after ICSI

Sponsors and collaborators

Lead sponsor

Shady Grove Fertility Reproductive Science Center

Other

Registry information

Important dates

Study start
2004
Study completion
2004
First posted
Jun 17, 2005
Registry last updated
Jun 24, 2005

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.