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Completed

NCT Number: NCT07415434

Laser-assisted Pontic Site Soft Tissue Healing Prior to Fixed Partial Denture Rehabilitation

This randomized placebo-controlled clinical trial aimed to evaluate the effect of laser-assisted therapy on soft tissue healing at the pontic site prior to fixed partial denture rehabilitation. Clinical healing outcomes, postoperative pain levels, and gingival crevicular fluid transforming growth factor beta-2 (TGF-β2) levels were assessed to determine the biological and clinical effects of laser therapy compared with placebo.

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Key information

Conditions

Soft Tissue Healing

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gaziantep University Faculty of Dentistry

Gaziantep, Turkey, 27310, Turkey (Türkiye)

About this study

Delayed or compromised soft tissue healing at the pontic site may prolong prosthetic treatment and negatively affect tissue stability and patient comfort. Photobiomodulation has been reported to enhance wound healing and modulate inflammatory and regenerative processes. This randomized placebo-controlled clinical trial evaluated the clinical and biological effects of laser-assisted therapy on pontic site healing prior to fixed partial denture rehabilitation. Clinical healing index scores, wound dimensions, postoperative pain levels, and gingival crevicular fluid TGF-β2 levels were assessed to investigate both clinical and biological aspects of healing.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Patients requiring single-tooth extraction followed by fixed partial denture rehabilitation
  • Patients in good general health
  • Patients willing to participate and able to provide informed consent

Exclusion criteria

  • Presence of systemic diseases that may affect wound healing (e.g., uncontrolled diabetes, immunological disorders)
  • Active periodontal disease at the study site
  • Use of medications affecting wound healing
  • Smoking or tobacco use
  • Pregnancy or lactation
  • History of radiotherapy in the head and neck region
  • Known contraindications to laser therapy

Treatment and study plan

GRR laser

Device

Low-level laser therapy applied once daily for five consecutive days following tooth extraction to enhance soft tissue healing at the pontic site.

Nd:Yag Laser

Device

Nd:YAG laser therapy applied once daily for five consecutive days following tooth extraction to promote soft tissue healing.

Sham Laser

Other

Placebo laser application performed under identical conditions without energy delivery.

Primary outcomes

  1. Clinical healing index (Landry, Turnbull and Howley Healing Index)

    Time frame: Baseline, Day 7, Day 14

    Clinical healing was assessed using the Landry, Turnbull and Howley Healing Index, which provides a single composite ordinal score ranging from 1 to 5, where higher scores indicate better soft tissue healing. The score is determined based on clinical evaluation of tissue color, bleeding on palpation, presence of granulation tissue, and degree of epithelialization at the pontic site.

Secondary outcomes

  1. Wound size reduction

    Time frame: Baseline, Day 7, Day 14

    Measurement of wound dimensions at the pontic site to evaluate soft tissue healing.

  2. Postoperative pain (VAS)

    Time frame: Baseline, Day 7, Day 14

    Postoperative pain intensity was assessed using a Visual Analog Scale (VAS) ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity.

  3. Gingival crevicular fluid TGF-β2 levels

    Time frame: Baseline, Day 7, Day 14

    Biochemical evaluation of transforming growth factor beta-2 levels in gingival crevicular fluid to assess biological aspects of wound healing.

Sponsors and collaborators

Lead sponsor

University of Gaziantep

Other

Registry information

Official study title

Laser-Assisted Pontic Site Soft Tissue Healing Prior to Fixed Partial Denture Rehabilitation: A Randomized Placebo-Controlled Clinical Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 17, 2026
Registry last updated
Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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