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NCT Number: NCT06478303

LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension

Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.

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Key information

Conditions

Corticospinal Excitability Cortical Activation

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Grenoble Alpes, Grenoble, Grenob, France

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • persons who have given written consent,
  • healthy subjects
  • subjects reading and understanding French
  • right-handed,
  • affiliated with a social security system,
  • between 18 and 40 years old,
  • had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.

Exclusion criteria

  • Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
  • Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
  • Characterized psychiatric pathology,
  • Ingestion of alcohol prior to the examination,
  • Persons covered by articles L1121-5 to L1121-8 of the CSP,
  • Presence of contraindications to MRI or TMS.

Treatment and study plan

motor imagery

Other

Participants were asked to imagine arm or foot movements.

Action reading

Other

Participants were asked to read sentences involving arm or foot movements

Motor localizer

Other

Participants were asked to perform arm or foot movements

Primary outcomes

  1. Level of corticospinal excitability

    Time frame: 1 hour and 30 minutes

    this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).

  2. Cortical activation (BOLD signal)

    Time frame: 1 hour

    this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).

Study contacts

Contact information is provided by the study sponsor or research team.

Laurent VERCUEIL

CONTACT

[email protected]

0476765561

William DUPONT

CONTACT

[email protected]

+33 (0)6 67 76 00 99

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Collaborators

  • University of Burgundy

Registry information

Acronym: LAMI

Important dates

Study start
2024
Primary completion
2027
Study completion
2028
First posted
Jun 27, 2024
Registry last updated
Aug 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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