Lactocare Baby Drops in Infants Colic

There is accumulating interest in role of lactobacilli in decreasing cry and fuss in infant colic, the condition that affects around 1 of 4-5 infants. The interest for dietary supplementation has been evoked by a line of earlier studies, indicating that infants with colic had an increased number of gas-forming E.coli in the intestines and potential interference between lactobacilli and E.coli. Systematic review of evidence, based on the 6 randomized controlled dietary studies, conducted in Italy, Poland, Australia, Canada, and Finland, has concluded of the decrease of the mean time cry of infant by -55 minutes a day after the 3 weeks dietary course with lactobacilli . In the mentioned studies most commonly used lactobacilli were L. reuteri, however, the effect of combination of L. reuteri with other lactobacilli remains unknown.

Inclusion criteria

• Informed consent form signed by both parents.
• Gender: males and females;
• Age: 4 -12 weeks;
• Infant colic, defined as cry/fussing lasting > 3 h, occurring > 3 d for 7 days;
• Gestational age 37-42 weeks;
• Birth weight 2,500-4,200 g;
• Stated availability throughout the study period;
• Sated availability of mobile phone or phone with answering machine.

Exclusion criteria

• Any formula feeding in any amount;
• Failure to thrive (weight gain less than 100 grams per week as averaged from the birth weight to the weight at entry);
• Current maternal smoking;
• Known moderate or severe disease of any systems (neural, skeletal, muscular, cutaneous, gastrointestinal, respiratory, genital, urinary, immune);
• Present intake of antibiotics by infant or mother;
• Present intake of prebiotics or probiotics by infant or mother;
• Difficulty of parents to comprehend study requirements as judged by the physician;
• Suspected parental alcohol or drug addiction as judged by the physician.