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Completed

NCT Number: NCT07149272

Lactate Kinetics Analysis Related to Low-Intensity Resistance Exercise

The goal of this study aims to analyze lactate kinetics as an exercise response after conventional multimodal exercise and virtual reality exercise (VRE) in hospitalized geriatric. The main question it aims to answer are:

1. are there any difference in post exercise lactate at day 1 and 7 between the two groups? 2. does the lactate concentration reduces after low intensity resistance exercise in subject with high resting lactate?

Participants were randomized into control and VRE group. Peripheral blood lactate was taken immediately before and after low-intensity resistance exercise at baseline and one week after

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Key information

Conditions

Fatigue Behavior Lactate Motor Activity Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

RSUPN Dr. Cipto Mangunkusumo

Jakarta Pusat, Jakarta Special Capital Region, 10430, Indonesia

About this study

Sixty geriatric patients were recruited during their hospitalization at RSUPN Dr. Cipto Mangunkusumo (RSCM). Subjects were randomized into control and intervention group. Both groups get conventional multimodal exercise, the intervention group gets additional VRE as adjuvant therapy. Exercise prescription was given after the subjects going through functional assessment conducted by physiatrists. The prescription described the frequency, intensity, interval, and type of exercise that is adjusted to subject's clinical condition. Each subject could have more than one type of exercise, but the most common combination consists of breathing, resistance, and aerobic exercises. VRAGMENT software was administered as VRE to the intervention group. In VRAGMENT, subjects should make phone call, groceries and making payment. Those activities in virtual environment initiated real movement of neck, trunk, arms, and legs. Capillary blood lactate sample was examined using StatStrip® from Nova Biomedical. Measurement range of StatStrip® is 0,3 - 20,0 mmol/L. Lactate examination conducts at baseline and one week after the exercise program. Blood samples were collected immediately pre and post-standardized low-intensity resistance training. The data collected were analyzed using SPSS statistics (version 24.0).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient age 60-90 years old in acute geriatric ward
  • mobilization level 3 and 4
  • able to communicate and follow instructions

Exclusion criteria

  • VR Sickness
  • severe psychosocial problems
  • severe caregiver burden

Treatment and study plan

Virtual Reality Exercise (VRE) using VRAGMENT software

Device

Adjuvant Virtual Reality Exercise (VRE) delivered via Oculus Quest 2 headset with VRAGMENT software, a culturally adapted VR program simulating daily activities (e.g., grocery shopping, phone calls) to induce physical movement. Participants received VRE alongside conventional multimodal exercise (breathing, resistance, aerobic) during hospitalization. Sessions were tailored to individual clinical conditions and aimed to improve fatigue and mobility through gamified rehabilitation

Other names: VRAGMENT

Primary outcomes

  1. Change in Post-Exercise Blood Lactate Concentration (mmol/L)

    Time frame: The change from pre- to post-exercise is measured on Day 1 and again on Day 7. The outcome is the comparison of these changes between the two days

    The absolute change in capillary blood lactate concentration (mmol/L) from pre-exercise to immediately post-exercise. This change will be calculated at two time points: at baseline (Day 1) and one week post-intervention (Day 7). The difference between the Day 7 change and the Day 1 change will be the primary outcome. Measurements will be taken using the StatStrip® Lactate Meter

Secondary outcomes

  1. Lactate Clearance Rate (% change per minute)

    Time frame: Measured during the recovery phase on Day 1 and Day 7. The outcome is the comparison of the clearance rates between the two days

    The rate at which blood lactate is cleared following exercise, calculated as the percentage decrease in lactate concentration from the immediate post-exercise peak to a subsequent measurement. This provides a kinetic measure of metabolic recovery

  2. Qualitative Pattern of Fatigue via Lactate Kinetics

    Time frame: Patterns are assessed by comparing the kinetic profiles from Day 1 to Day 7

    A qualitative assessment of the overall lactate kinetic response (combining the post-exercise change and clearance rate) to infer clinical patterns of fatigue improvement

Sponsors and collaborators

Lead sponsor

Dr Cipto Mangunkusumo General Hospital

Other

Registry information

Official study title

Lactate Kinetics Analysis Related to Low-Intensity Resistance Exercise: Randomized Control Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 29, 2025
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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