Skip to main content
OpenTrials
Completed

NCT Number: NCT01482247

L-Arginine, Vascular Response and Mechanisms

The purpose of the study is to employ the supplement L-arginine to test the hypothesis that activation of blood flow to the brain during cognitive tasks is regulated by nitric oxide in older subjects with diabetes mellitus and/or hypertension (high blood pressure).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypertension Cardiovascular Diseases Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Vascular Diseases

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diabetes and/or hypertension

Exclusion criteria

  • alzheimers disease, dementia, stroke, active herpes, recent angina or heart attack

Treatment and study plan

L-Arginine

Dietary Supplement

Dietary Supplement

Placebo supplement

Dietary Supplement

Dietary Supplement

Primary outcomes

  1. Functional transcranial doppler measures

    Time frame: 6 weeks

Secondary outcomes

  1. Flow Mediated Dilation (FMD)

    Time frame: 6 weeks

  2. Finger Blood Flow - Plethysmography (PAT)

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Nov 30, 2011
Registry last updated
Jul 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.