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NCT Number: NCT06067867

Kidney and Pregnancy Registry

Maternal physiological adaptation to pregnancy plays an important role in the smooth progress of the pregnancy and the healthy growth of the fetus. This physiological adaptation takes place at the level of several organs, including the kidney. Physiological changes during a normal pregnancy take place at the anatomical, glomerular and tubular level.

In the event of pre-existing kidney damage (glomerular and tubular diseases, stone disease, high blood pressure (hypertension) etc...) these adaptations will not be optimal. This will have implications for:

* the course of the pregnancy with the occurrence of feto-maternal complications: miscarriages, pre-eclampsia, intrauterine growth retardation (IUGR), low birth weight, prematurity. The risk of feto-maternal complications increases with the degree of renal failure or with certain pathologies such as lupus. * progression of kidney disease

Some maternal complications have long-term implications: preeclampsia is associated with a high risk of subsequent cardiovascular and renal complications. Pregnancies in these patients are high-risk pregnancies and require specialized management by an experienced group of gynecologists and nephrologists.

The creation of a retrospective and prospective register by collecting demographic, clinical, biological, radiological and genetic data concerning patients at each consultation within the CHU Brugmann Hospital will allow:

* to establish the epidemiological and clinico-biological characteristics of the patients followed at the Kidney and Pregnancy Clinic at the CHU Brugmann Hospital * to analyze the risk factors for feto-maternal complications * to analyze the risk factors for the occurrence of subsequent cardio-renal pathologies in patients who have had preeclampsia or an event during their pregnancy * to identify patients who will need specialized genetic testing

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Key information

Conditions

Kidney Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

CHU Brugmann

Brussels, 1020, Belgium

Location status: Recruiting

Location contact

Christelle Fosso

CONTACT

[email protected]

3224772016

Christelle Fosso

PRINCIPAL_INVESTIGATOR

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pre-conception consultations

Woman of childbearing age with:

  • Renal damage (glomerular, tubular disease, renal lithiasis, systemic disease, metabolic diseases, congenital diseases, etc.)
  • Hematological disorders (sickle cell disease)
  • Kidney transplantation
  • High blood pressure (hypertension)
  • Pre-kidney transplant assessment in progress for discussion of contraception and pregnancy after kidney transplantation
  • Preeclampsia
  • Multiple miscarriages
  • IUGR and low birth weight in the fetus
  • Family history of kidney disease
  • Peri-gravid consultations

Pregnant women with

  • Pre-existing kidney damage
  • De novo renal failure (IR)
  • Proteinuria
  • Hematuria
  • Chronic hypertension
  • Pregnancy hypertension
  • Renal lithiasis
  • Postpartum consultations

Postpartum women with

  • Early/late pre-eclampsia
  • Eclampsia / Hemolysis Elevated Liver enzymes Low Platelet (HELLP) syndrome
  • Pregnancy hypertension
  • Postpartum hemorrhage
  • De novo renal failure postpartum

Exclusion criteria

Male patients Menopausal patients

Treatment and study plan

Data extraction from medical files

Other

Data extraction from medical files

Primary outcomes

  1. Epidemiological characteristics of patients

    Time frame: 20 years

  2. Clinico-biological characteristics of patients

    Time frame: 20 years

  3. Risk factors for feto-maternal complications

    Time frame: 20 years

  4. Risk factors for cardio-renal pathologies

    Time frame: 20 years

    Risk factors for the occurrence of subsequent cardio-renal pathologies in patients who had preeclampsia or an event during their pregnancy

  5. Need for genetic testing

    Time frame: 20 years

    Identification of patients who will need specialized genetic testing

Study contacts

Contact information is provided by the study sponsor or research team.

Christelle Fosso

CONTACT

[email protected]

3224772016

Sponsors and collaborators

Lead sponsor

Brugmann University Hospital

Other

Registry information

Important dates

Study start
2023
Primary completion
2043
Study completion
2043
First posted
Oct 5, 2023
Registry last updated
Oct 5, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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