Skip to main content
OpenTrials
Completed

NCT Number: NCT02573441

KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer

The study will examine whether school liaison services and home-based parental tutoring can help with academic difficulties of paediatric brain tumour survivors who received cranial spinal radiation and have returned to school. Forty-five patients will participate in the project. All patients will receive psychology liaison services to link resources at the hospital with those in the community. Patients will participate in one of two tutoring programs designed to directly or indirectly improve math skills over 12 weeks. Weekly phone calls will be used to support parents using the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities.

Completed

Looking for future studies?

Notify Me

Key information

Age range

6 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

About this study

Paediatric brain tumour survivors who receive cranial spinal radiation have learning problems, particularly in mathematics and working memory. Working memory is often described as a "mental workspace" where relevant information is held in mind and processed. Working memory is important in mathematics for holding in mind relevant information and carrying out steps necessary to solve problems.

This study will examine whether school liaison support and home-based parental tutoring can help address the academic difficulties of paediatric brain tumour survivors who have received cranial spinal radiation and who have returned to their community school. Forty five patients will participate in the project. First, all patients will receive psychology liaison services to link resources at the hospital with those in the community in order to provide information regarding the effects of pediatric cancer on learning and facilitate the implementation of appropriate assistive technology and remediation programs. Patients will then participant in one of two tutoring programs over the course of a 12 week period. One group of patients will participate in a program that addresses working memory with the intent of indirectly helping with mathematics skills. This program will be delivered over the internet. Another group of patients will participate in a program using a work book to directly help improve mathematics skills. Weekly phone calls will be used to support parents in doing the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities. The two intervention programs will be compared to a waitlist control group that receives only the liaison service (including academic support through weekly phone calls over the 12 weeks).

The findings from this study will provide evidence about the type of intervention that is most effective at helping paediatric brain tumour survivors improve their mathematics skills and working memory ability.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Has been diagnosed with a brain tumour and treated with cranial radiation
  • Is between 1 and 10 years following diagnosis
  • Has English as his or her native language or has had at least two years of schooling in English
  • Is between the ages of 6 and 17
  • Less than a Grade 8 equivalent math score

Exclusion criteria

  • Is younger than 6 years or older than 17 years of age
  • Is receiving palliative care

Treatment and study plan

Jump Math

Behavioral

Jump Math is a workbook based program aimed at improving math skills

Cogmed

Behavioral

Cogmed is an online computer program aimed at improving working memory skills

Liaison Services

Behavioral

Liaison Services will include working closely with schools to help explain the strengths and weaknesses of a child based on cognitive testing and to help with the implementation of recommendations

Primary outcomes

  1. Woodcock Johnson Academic-Third Edition

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of math Fluency, applied math problems, and qualitative concepts

  2. Wechsler Intelligence Scale for Children - Fourth Edition Integrated

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of verbal and visual working memory

  3. Wide Range Assessment of Memory and Learning - Second Edition

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of verbal and visual working memory

  4. Automated Working Memory Assessment

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of verbal and visual working memory

  5. Connors' Continuous Performance Test-Second Edition

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of sustained attention

  6. Behaviour Rating Inventory of Executive Function-Parent Version

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of executive functioning

  7. Monitoring Basic Skills Progress

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of mathematics

Secondary outcomes

  1. SAM

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of participants attitude towards math

  2. Wide Range Assessment of Memory and Learning - Second Edition

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of visual learning and memory

  3. California Verbal Learning Test, Children's Version

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of verbal learning and memory

  4. CANTAB

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    Measures of processing speed

  5. Wechsler Abbreviated Scale of Intelligence - Second Edition

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    A measure of vocabulary and abstract visual reasoning

  6. Delis-Kaplan Executive Function System

    Time frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up

    Measures of processing speed and switching attention

Sponsors and collaborators

Lead sponsor

The Hospital for Sick Children

Other

Collaborators

  • Pediatric Oncology Group of Ontario

Registry information

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
Oct 9, 2015
Registry last updated
Jul 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.