Biomarkers of Brain Injury in Children With Brain Tumors

Inclusion criteria

, Group A (treated with radiation):

• Age 0-17 years old, AND
• Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic method (e.g., for germinoma) at Uppsala University Hospital or at another university hospital in Sweden, AND
• Referred for radiotherapy at Skandion Clinic in Uppsala and/or at their local hospital (in some cases), with/without the addition of other cancer treatments.

Inclusion criteria

, Group B (treated without radiation/radiation naive):

• Age 0-17 years old, AND
• Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic method (e.g., for optic pathway glioma in neurofibromatosis type 1 and germinoma) at Uppsala University Hospital or at another university hospital in Sweden, AND
• Not referred to radiotherapy and treated with/without the addition of other cancer treatments.

Inclusion criteria

, Group C (healthy control group):

• Age 0-17 years old at time of recruitment

Exclusion criteria

, Groups A + B:

• Diagnosed with a tumor only in the spinal cord (solitary spinal tumor).
• Diagnosed with a tumor considered palliative already at diagnosis (e.g., diffuse intrinsic pontine glioma)

Exclusion criteria

, Group C:

• Have diagnosis of chronic disease that requires continuous medication.

Exclusion criteria

, all groups:

• Unable to provide informed consent due to language difficulties.