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Active, Not Recruiting

NCT Number: NCT06846840

Ketone Esters and Metabolism During Recovery from Endurance Exercise

Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.

The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Exercise Behavior Metabolism Motor Activity

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Bath

Bath, BA2 7AY, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • VO2max ≥ 45mL.kg-1.min-1
  • Weekly aerobic training > 3hours.
  • 2years running experience.
  • BMI < 30kg/m2

Exclusion criteria

  • <18yrs or >60yrs of age
  • Habitual smoker within last 5 years.
  • History of uncontrollable metabolic or respiratory disease.
  • Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements.
  • History of Irritable Bowel Syndrome

Treatment and study plan

Ketone ester

Dietary Supplement

0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl

Placebo

Dietary Supplement

Medium chain triglycerides and bitter tastant (Bitrex)

Primary outcomes

  1. Glucose concentrations

    Time frame: 240 minutes

    Blood glucose concentrations during the recovery period (240 minutes)

Secondary outcomes

  1. Non-oxidative fate of ingested sucrose

    Time frame: 240 minutes

    Non-oxidative fate of ingested glucose measured by appearance of 13C on breath CO2 from high 13C sucrose ingested during recovery

  2. Exercise capacity

    Time frame: 240 minutes

    Time to exhaustion running at 70% of maximal aerobic capacity after the recovery period

Other outcomes

  1. Blood beta-hydroxybutyrate concentrations

    Time frame: 240 minutes

    Blood beta-hydroxybutyrate concentrations throughout the 240 minute recovery

  2. Urinary urea

    Time frame: 240 minutes

    Urea in urine, determined by urea concentration multiplied by total urine output during the 240 minutes of recovery

  3. Blood lactate concentrations

    Time frame: 240 minutes

    Blood lactate concentrations during 240 minutes of recovery

  4. Plasma insulin concentrations

    Time frame: 240 minutes

    Plasma insulin concentrations during 240 minutes of recovery

  5. Blood pH

    Time frame: 240 minutes

    Blood pH during 240 minutes of recovery

  6. Blood bicarbonate

    Time frame: 240 minutes

    Blood bicarbonate concentrations during 240 minutes of recovery

Sponsors and collaborators

Lead sponsor

University of Bath

Other

Registry information

Official study title

Effect of Ketone Esters Ingested During Recovery on Metabolism and Subsequent Exercise Capacity

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 26, 2025
Registry last updated
Feb 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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