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Completed

NCT Number: NCT02570230

Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

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Key information

Conditions

Pain Neurologic Manifestations Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Period Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA physical status 1-3
  • elective thoracotomy
  • can operate patient-controlled analgesia (PCA) machine

Exclusion criteria

patient with history of

  • allergy to morphine or ketamine
  • contraindicate to ketamine
  • remain intubated in the postoperative period

Treatment and study plan

NSS

Other

NSS infusion

ketamine

Drug

Ketamine 0.2 mg/kg/hr intravenous infusion

Primary outcomes

  1. Time to first trigger of morphine

    Time frame: 24 hours

    Time to first trigger of morphine

Secondary outcomes

  1. 24-hr morphine consumption

    Time frame: 24 hours

    24-hr morphine consumption

  2. NRS score at 6, 24 hours

    Time frame: 24 hours

    NRS score (0-10) was assessed at at 6, 24 hours postoperative

  3. Incidence of nausea and vomiting

    Time frame: 24 hours

    Incidence of nausea and vomiting

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Oct 7, 2015
Registry last updated
Sep 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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