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Completed

NCT Number: NCT02044445

Is the IVF Outcome Dependent on the Time Interval Between hCG Administration and Oocyte Retrieval?

During controlled ovarian hyperstimulation (COH), human chorionic gonadotrophin (hCG) is administered to trigger the final follicular maturation before oocyte retrieval, in an attempt to mimic the physiologic effects of LH. The hCG is administered when more than three follicles ≥17mm in mean diameter have developed.

The time interval between hCG administration and oocyte retrieval is of critical importance since the time after luteinizing stimulus is a period of intense processes including the start of luteinization, expansion of cumulus cells and oocyte meiotic maturation.

The commonly practiced hCG administration time of 33 to 36 h in most IVF cycles aims to avoiding spontaneous ovulation before oocyte retrieval. However, several studies have shown that significantly more high quality embryos have been obtained with a prolonged hCG-to-oocyte interval of 38 h. It has been hypothesized that longer interval would be beneficial in improving oocyte quality and achieving optimal maturation.

Currently there are no data on the effect of the time interval between hCG administration and oocyte retrieval on IVF outcome in GnRH antagonist cycles. The aim of this study is to determine whether there is any difference in in vitro fertilization outcome when oocyte retrieval takes place at 36 h or 38 h following hCG administration

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Key information

Conditions

Subfertility Genital Diseases Infertility Urogenital Diseases

Age range

20 year–43 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Unit for Human Reproduction, 1st Dept of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki

Thessaloniki, Greece

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women undergoing fresh IVF cycle with recombinant FSH and GnRH antagonists
  • regular spontaneous menstrual cycle (24-35 days)
  • age ≤ 43 years
  • FSH ≤ 20 IU/L

Exclusion criteria

  • History of previous ovarian surgery
  • Women with Stage III-IV Endometriosis
  • Women undergoing natural cycle IVF

Treatment and study plan

Oocyte retrieval will be performed 36 h or 38 h after hCG administration

Procedure

Oocyte retrieval will be performed 36 h or 38 h after hCG administration

Other names: oocyte retrieval at 36 hours following hCG administration, oocyte retrieval at 38 hours following hCG administration

Primary outcomes

  1. retrieval rate (cumulus-oocyte complexes/ follicles> 11 mm)

    Time frame: up to 38 h after hCG administration

Secondary outcomes

  1. Clinical pregnancy rate (evidence of intrauterine sac with fetal heart activity at 6-8 weeks of gestation)

    Time frame: At 6-8 weeks of gestation

  2. Total number of oocytes retrieved

    Time frame: up to 38 h after hCG administration

Sponsors and collaborators

Lead sponsor

Aristotle University Of Thessaloniki

Other

Registry information

Important dates

Study start
2009
Primary completion
2013
First posted
Jan 24, 2014
Registry last updated
May 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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