Iron Overload in Stem Cell Transplant Recipients

The goal of this study is to examine the impact of iron overload in patients undergoing a bone marrow transplant. We believe that the iron status in these patients is associated with complications for transplant survivors. We will examine the iron status in these patients by MRI and by screening for mutations in genes known to cause iron overload. We will also determine the levels of hepcidin (a hormone produced in the liver that appears to regulate iron homeostasis) from blood and urine.

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Key information

Conditions

Iron Overload Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hemochromatosis Iron Metabolism Disorders Metabolic Diseases Metabolism, Inborn Errors Metal Metabolism, Inborn Errors Nutritional and Metabolic Diseases

Age range

5 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Children's Hospital Boston

Boston, Massachusetts, 02115, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Undergoing allogeneic HSCT for malignant or non-malignant conditions
Age greater than or equal to 5 years
Able to undergo MRI without a need for general anesthesia
No metal implants
Signed informed consent (by parent if patient is less than 18 years old, or by patient, if he or she is greater than 18 years old).

Treatment and study plan

Primary outcomes

Hepatic iron content as measured by R2 MRI.

Time frame: Pre-HSCT and Day 100

Secondary outcomes

Genetic determinants of iron overload- HFE status.

Time frame: Pre-HSCT

Sponsors and collaborators

Lead sponsor

Boston Children's Hospital

Other

Collaborators

Dana-Farber Cancer Institute
Lance Armstrong Foundation

Registry information

Official study title

Impact of Iron Overload in Pediatric Patients Undergoing Stem Cell Transplantation

Important dates

Study start: 2007
Primary completion: 2010
Study completion: 2010
First posted: Dec 11, 2008
Registry last updated: Mar 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed