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Completed

NCT Number: NCT05988476

Investıgatıon of The Effıciency of Pulsed Electromagnetıc Field Therapy and Stretching Exercises

In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time. In the study, animals were divided into 5 groups (Control, INJ, INJ+Exercise, INJ+PEMF, INJ+Exercise+PEMF). Experimental animals were sacrificed on the 7th and 14th days to see the effects of the treatments. At the end of the experiment, genetic, histopathological, and immunohistochemical evaluations were made in the muscle tissue.

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Key information

Conditions

Muscle Injury Bone Diseases Bone Diseases, Developmental Camurati-Engelmann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities Fibrosis Genetic Diseases, Inborn Muscle Stretching Exercise Musculoskeletal Diseases Osteochondrodysplasias Pathologic Processes Pathological Conditions, Signs and Symptoms Pulsed Electromagnetic Therapy

Age range

10 month–11 month

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

SuleymanDU

Isparta, Turkey (Türkiye)

About this study

Purpose: The aim of this study was to evaluate the efficacy of stretching exercise and the pulsed electromagnetic field (PEMF) method in the treatment of muscle injury (INJ).

Methods: In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time. In the study, animals were divided into 5 groups (Control, INJ, INJ+Exercise, INJ+PEMF, INJ+Exercise+PEMF). Experimental animals were sacrificed on the 7th and 14th days to see the effects of the treatments. At the end of the experiment, genetic, histopathological, and immunohistochemical evaluations were made in the muscle tissue.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy young wistar albino rats

Exclusion criteria

  • not having any injury

Treatment and study plan

Exercise

Other

5 day/week, two week, one session stretching exercises consisting of ten repetitions of one minute

Pulsed Electromagnetic Field Therapy

Device

5 day/week, two week,two sessions consisting of 180 minutes

Primary outcomes

  1. Mononuclear cell infiltration, Atrophy and necrosis, Pyknotic nucleus assesment at the end of two weeks

    Time frame: two week

    hematoxylin-eosin staining

  2. VEGF and FGF assesment at the end of two weeks

    Time frame: two week

    immunohischemical staining

  3. TGF-β1, eNOS assesment at the end of two weeks

    Time frame: two week

    Quantitative Reverse-Transcriptase Polymerase Chain Reaction (RT-qPCR)

Sponsors and collaborators

Lead sponsor

Suleyman Demirel University

Other

Registry information

Official study title

Investigation of The Efficiency of Pulsed Electromagnetic Field Treatment and Stretching Exercise In Experimental Skeletal Muscle Injury Model

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Aug 14, 2023
Registry last updated
Aug 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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